ReviewThe American journal of gastroenterology2026
Adenomatous Polyposis Coli Gene Polyposis-Related Syndromes.
Review in The American journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Gastrointestinal cancers, particularly those of the stomach and colorectum, are among the leading causes of cancer-related morbidity and mortality in the United States and worldwide. The adenomatous polyposis coli ( APC ) gene functions as a tumor suppressor gene whose loss of function plays a critical role in gastrointestinal cancer development. Pathogenic/likely pathogenic variants of the APC gene are associated with intestinal (gastric, small bowel, and colorectal neoplasia) and extra-intestinal manifestations. In this narrative review, we discuss the epidemiology, diagnosis, and management of APC gene-related polyposis syndromes. We also review the variation in genotype-phenotype presentations and discuss practical aspects of caring for individuals affected by these syndromes with an emphasis on multidisciplinary care, family planning, and transitions of care.
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