Evidence map›Paper›PMID 41504249›Full record

ArticleACS infectious diseases2026

Ruthenium Complexes Containing Thiobenzamide Act as Potent and Selective Anti-

Maria Vitória Gomes das Neves, Isabela Santos Cezar, Edivaldo Dos Santos Rodrigues, Felipe Cardoso Teixeira Bomfim, Ricardo da Silva Duarte, Claudia Valeria Campos de Souza, Vinícius Pinto Costa Rocha, Denise Santos de Sá, Osvaldo Andrade Santos-Filho, Carlos Daniel Silva da Silva and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria Vitória Gomes das NevesGonçalo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador, Bahia 40296-710, Brazil.
Isabela Santos CezarGonçalo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador, Bahia 40296-710, Brazil.
Edivaldo Dos Santos RodriguesLaboratory of Molecular Modeling and Computational Structural Biology, Walter Mors Natural Products Research Institute, Health Sciences Center, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.
Felipe Cardoso Teixeira BomfimDepartment of Chemistry, Federal Institute of Bahia, IFBA, Salvador, Bahia 40301-015, Brazil.
Ricardo da Silva DuarteDepartment of Chemistry, Federal Institute of Bahia, IFBA, Salvador, Bahia 40301-015, Brazil.
Claudia Valeria Campos de SouzaLaboratory of Molecular Modeling and Computational Structural Biology, Walter Mors Natural Products Research Institute, Health Sciences Center, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.
Vinícius Pinto Costa RochaGonçalo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador, Bahia 40296-710, Brazil.
Denise Santos de SáDepartment of Chemistry, Federal Institute of Bahia, IFBA, Salvador, Bahia 40301-015, Brazil.
Osvaldo Andrade Santos-FilhoLaboratory of Molecular Modeling and Computational Structural Biology, Walter Mors Natural Products Research Institute, Health Sciences Center, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.ORCID 0000-0001-7407-158X
Carlos Daniel Silva da SilvaDepartment of Chemistry, Federal Institute of Bahia, IFBA, Salvador, Bahia 40301-015, Brazil.
Milena Botelho Pereira SoaresGonçalo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador, Bahia 40296-710, Brazil.
Cássio Santana MeiraGonçalo Moniz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Salvador, Bahia 40296-710, Brazil.ORCID 0000-0002-7578-3615

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas disease remains a significant global health concern, with current therapies limited to benznidazole and nifurtimox, which have adverse effects and show reduced efficacy in the chronic phase. This study investigated ruthenium complexes with or without thiobenzamide (Tbz). FOR0012A and FOR0212A, both containing Tbz, showed potent trypanocidal activity, with IC

Indexed as

ApoptosisBenzamidesChagas DiseaseRutheniumTrypanocidal AgentsTrypanosoma cruziAnimalsMiceMolecular Docking SimulationNADH, NADPH OxidoreductasesOxidative StressBenzamidesNADH, NADPH OxidoreductasesRutheniumTrypanocidal Agentstrypanothione reductaseChagas diseasemolecular dockingruthenium complexesT. cruzithiobenzamidetryponathione reductase

Identifiers

PMID41504249
PMCPMC12910599

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.