Evidence map›Paper›PMID 41504169›Full record

ReviewChemistry & biodiversity2026

Quorum-Sensing Inhibitors as Potential Antibacterial Agents Against Staphylococcus aureus: A Comprehensive Review.

Shrestha Palit, Bharat Kumar Reddy Sanapalli, Sharon Blessy Manda, Vaishnavi Munnangi, Ashwini Deshpande, Vidyasrilekha Sanapalli

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shrestha PalitSchool of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Deemed-to-be-University, Hyderabad, India.
Bharat Kumar Reddy SanapalliDepartment of Pharmacology, School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Deemed-to-be-University, Hyderabad, India.ORCID https://orcid.org/0000-0002-9162-5553
Sharon Blessy MandaDepartment of Pharmacology, School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Deemed-to-be-University, Hyderabad, India.
Vaishnavi MunnangiDepartment of Pharmacology, School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Deemed-to-be-University, Hyderabad, India.
Ashwini DeshpandeDepartment of Pharmaceutics, School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Deemed-to-be-University, Hyderabad, India.
Vidyasrilekha SanapalliDepartment of Pharmaceutical Chemistry, School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Deemed-to-be-University, Hyderabad, India.ORCID https://orcid.org/0000-0001-8298-1161

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Staphylococcus aureus is an important pathogen in humans, responsible for a wide range of community-acquired and nosocomial infections, and is especially known for its antibiotic resistance. Traditional therapies are increasingly failing, necessitating new approaches to antimicrobial therapy. One promising strategy involves the use of quorum-sensing inhibitors (QSIs) that target the communication systems of bacteria responsible for the regulation of virulence, toxin production, and biofilm formation. In this review, we provide an overview of QSIs by dividing the natural and synthetic QSIs and also their mechanism of action, the in vitro and in vivo assessments performed, and potential synergy with the conventional antibiotics. Literature was comprehensively reviewed from PubMed, Scopus, and Web of Science databases according to PRISMA guidance. QSIs showed great potential in interfering with the pathogenicity of S. aureus, especially with the accessory gene regulator (Agr) system. Nonetheless, bioavailability, selectivity, and translational issues persist. The review underlines the therapeutic potential and prospects of QS inhibition as an alternative antibacterial approach against S. aureus.

Indexed as

Anti-Bacterial AgentsQuorum SensingStaphylococcus aureusHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAgr systemantibacterial resistancequorum sensingStaphylococcus aureus

Identifiers

PMID41504169
PMCPMC13420220

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.