Evidence map›Paper›PMID 41504151›Full record

ArticleChemistry & biodiversity2026

Alkaloid Components From Orychophragmus violaceus and Their Ferroptosis Inhibition Activity.

Xiao-Lan Chen, Jin-Peng Lv, Rui-Hong Li, Chun-Bo Ge, Yu-Ying Wang, Shu-Chen Liu, Guang-Jie Zhang

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Impact of Oxidative Stress-Driven Ferroptosis in Neurodegeneration.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiao-Lan ChenBeijing Institute of Radiation Medicine, Beijing, China.
Jin-Peng LvBeijing Institute of Radiation Medicine, Beijing, China.
Rui-Hong LiBeijing Institute of Radiation Medicine, Beijing, China.
Chun-Bo GeBeijing Institute of Radiation Medicine, Beijing, China.
Yu-Ying WangBeijing Institute of Radiation Medicine, Beijing, China.
Shu-Chen LiuBeijing Institute of Radiation Medicine, Beijing, China.
Guang-Jie ZhangBeijing Institute of Radiation Medicine, Beijing, China.ORCID https://orcid.org/0000-0002-2628-7455

Funding

National Natural Science Foundation of China 81903497
6 · The paper itself

Abstract

Three new alkaloids (1-3), together with three known alkaloids (4-6), were isolated from the seeds of Orychophragmus violaceus. Their structures were elucidated by spectroscopic data analysis and ECD calculations. All compounds were assessed to evaluate their ferroptosis inhibition activity. Notably, compound 3 specifically inhibited erastin-induced ferroptosis in human intestinal epithelial cells (HIEC-6). Moreover, compound 3 significantly decreased the accumulation of reactive oxygen species (ROS), Fe

Indexed as

AlkaloidsFerroptosisCell LineDose-Response Relationship, DrugGlutathioneHumansMolecular StructurePiperazinesReactive Oxygen SpeciesSeedsStructure-Activity RelationshipAlkaloidserastinGlutathionePiperazinesReactive Oxygen Speciesalkaloidschemical structureferroptosis inhibitionOrychophragmus violaceus

Identifiers

PMID41504151
PMCPMC13420215

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.