Evidence map›Paper›PMID 41504111›Full record

ArticleEpigenomics2026

Inter-individual differentially methylated region-targeted EWAS reveals epigenetic signatures of early childhood adversity.

Taira Mayanagi, Junko Yagi, Hideki Ohmomo, Manami Akasaka, Kentaro Fukumoto, Shusaku Chiba, Shohei Komaki, Atsushi Shimizu, Takehito Yanbe, Mare Uchide and 8 more

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In one paragraph

Article in Epigenomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Taira MayanagiDepartment of Neuroscience, Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Japan.ORCID 0000-0002-7984-186X
Junko YagiDepartment of Neuropsychiatry, School of Medicine, Iwate Medical University, Yahaba, Japan.
Hideki OhmomoDivision of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Japan.ORCID 0000-0002-3524-6524
Manami AkasakaDepartment of Pediatrics, School of Medicine, Iwate Medical University, Yahaba, Japan.
Kentaro FukumotoDepartment of Neuropsychiatry, School of Medicine, Iwate Medical University, Yahaba, Japan.ORCID 0000-0002-7827-4146
Shusaku ChibaDepartment of Clinical Psychology, Iwate Medical University Hospital, Iwate Medical University, Yahaba, Japan.
Shohei KomakiDivision of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Japan.ORCID 0000-0002-0486-3239
Atsushi ShimizuDivision of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Japan.ORCID 0000-0001-8307-2461
Takehito YanbeDepartment of Neuropsychiatry, School of Medicine, Iwate Medical University, Yahaba, Japan.
Mare UchideDepartment of Neuropsychiatry, School of Medicine, Iwate Medical University, Yahaba, Japan.
Yasuhito YoshiokaDepartment of Neuropsychiatry, School of Medicine, Iwate Medical University, Yahaba, Japan.
Kaori OgawaDepartment of Clinical Psychology, Iwate Medical University Hospital, Iwate Medical University, Yahaba, Japan.
Chiho IshikawaIwate Child Mental Health Care Center, Disaster Reconstruction Center, Iwate Medical University, Yahaba, Japan.
Shiori MinabeDivision of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Japan.ORCID 0000-0001-7902-925X
Jun ItoDepartment of Pediatrics, School of Medicine, Iwate Medical University, Yahaba, Japan.
Kanako OnoDivision of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, Yahaba, Japan.
Nozomi KanekoIwate Child Mental Health Care Center, Disaster Reconstruction Center, Iwate Medical University, Yahaba, Japan.
Kenji SobueDepartment of Neuroscience, Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsAdverse childhood experiences (ACEs), especially in early life, can affect psychosocial development and increase lifelong risk for mental disorders. ACEs are also known to induce persistent epigenetic changes. This study aimed to explore ACE-associated DNA methylation signatures using an epigenome-wide association study (EWAS) targeting inter-individual differentially methylated regions (DMRs).

methodsWe developed a targeted capture probe system covering ~1.3 million CpG sites within inter-individual DMRs. This system was applied to salivary DNA from drug-naïve children aged 6-12 years with exposure to multiple early-life ACEs (

resultsWe identified 15 novel DMRs significantly associated with ACEs. A cluster of six CpG sites within an exon of the

conclusionOur findings suggest that early adversity may contribute to lasting epigenetic modifications in children. The identified DMRs may serve as noninvasive biomarkers for retrospective ACE assessment and provide insights into the biological embedding of early-life stress.

Indexed as

Adverse Childhood ExperiencesDNA MethylationEpigenesis, GeneticChildCpG IslandsFemaleGenome-Wide Association StudyHumansMaleadverse childhood experienceDNA methylationepigenome-wide association studyinter-individual differentially methylated regionsaliva DNA

Identifiers

PMID41504111
PMCPMC12826735

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.