ArticleChemistry & biodiversity2026
Placidenes G-J, Bioactive γ-Pyrone Derivatives From the Marine Mollusk Placida dendritica.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Three pairs of undescribed enantiomeric γ-pyrone derivatives placidenes G-I (1-3), together with two new congeners placidene J (4)/isoplacidene J (5) and two known compounds 6 and 7, were isolated from the marine mollusk Placida dendritica. Compounds 1a/1b-3a/3b were further separated by chiral-phase high-performance liquid chromatography. The structures were elucidated by comprehensive spectroscopic analysis, high-resolution electrospray ionization mass spectrometry, time-dependent density functional theory/electronic circular dichroism calculation, and X-ray diffraction analysis. In bioassays, compounds 1-5 exhibited moderate nitric oxide inhibition from 28.2% to 51.9% on RAW264.7 inflammatory cells at 20 µM without notable cytotoxicity.
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