Evidence map›Paper›PMID 41504076›Full record

ArticleChemistry & biodiversity2026

Antiproliferative Effect of Okra Seed Protein Isolate against HepG2 and A549 Cell Lines.

Letisha Maistry, Abe Shegro Gerrano, John J Mellem

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Letisha MaistryDepartment of Biotechnology and Food Science, Durban University of Technology, Durban, South Africa.
Abe Shegro GerranoAgricultural Research Council - Vegetable, Industrial and Medicinal Plants, Pretoria, South Africa.
John J MellemDepartment of Biotechnology and Food Science, Durban University of Technology, Durban, South Africa.ORCID https://orcid.org/0000-0002-4784-699X

Funding

Durban University of Technology and the National Research Foundation 735336
6 · The paper itself

Abstract

Cancer is a non-communicable disease and is one of the leading causes of mortality worldwide. While plant-derived compounds have exhibited promise in cancer therapy, the biological activity of okra seed protein isolate (OSPI) has not been extensively explored. The present study evaluates the antiproliferative effect of OSPI against human liver hepatocellular carcinoma (HepG2) and lung adenocarcinoma (A549) cancer cell lines using in vitro assays. The protein isolate exhibited cytotoxic effects by reducing A549 cell viability significantly (37.73%), with an IC

Indexed as

AbelmoschusAntineoplastic Agents, PhytogenicPlant ProteinsSeedsA549 CellsApoptosisCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHep G2 CellsHumansReactive Oxygen SpeciesStructure-Activity RelationshipAntineoplastic Agents, PhytogenicPlant ProteinsReactive Oxygen Speciesapoptosiscaspasecaspase 3/7caspase 8okrap53proteinsROS

Identifiers

PMID41504076
PMCPMC12781165

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.