ArticleJournal of psychopharmacology (Oxford, England)2026
Associations between glutamate and cerebral blood flow in treatment-resistant schizophrenia during clozapine treatment.
Article in Journal of psychopharmacology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Cytokine and C-reactive protein concentrations over 6 months of treatment with clozapine in treatment resistant schizophrenia.Brain, behavior, & immunity - health · 2026Article
- Longitudinal brain structural changes during clozapine treatment: associations with neuroreceptor architecture and clinical response.medRxiv : the preprint server for health sciences · 2026Article
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Authors and funding
13 authors.
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Abstract
backgroundTreatment-resistant schizophrenia (TRS) is associated with alterations in glutamate levels and cerebral blood flow (CBF), and treatment with clozapine appears to have an impact on each of these measures. Here, we examined whether changes in CBF and glutamate levels following clozapine treatment are related.
methodsGlutamate concentrations in the anterior cingulate cortex (ACC), and striatum (measured using proton magnetic resonance spectroscopy,
resultsThe longitudinal change in striatal glutamate during treatment was positively associated with the longitudinal change in striatal CBF (
conclusionsThese results indicate that there is a direct relationship between changes in glutamate activity and CBF in the striatum following clozapine treatment. Future research could investigate whether glutamate-CBF relationships exist in other stages of psychosis or schizophrenia and during treatment with other antipsychotic medications. Associations with clinical outcomes could be explored in larger samples.
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