Evidence map›Paper›PMID 41504026›Full record

ArticleChemistry & biodiversity2026

Silk Fibroin-Stabilized Lapachol Microemulsion Enhances Antiglioma Activity In Vitro.

Jardel P Queiroz, Fábio R Oliveira, Eline Gomes Santos, Fabrício Holanda, Victor Marinho, Edilene Oliveira da Silva, José Carlos T Carvalho, Caio P Fernandes, Barbarella M Macchi, Irlon M Ferreira and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jardel P QueirozPrograma De Pós-Graduação Em Farmacologia e Bioquímica, Universidade Federal do Pará, Belém, Brazil.
Fábio R OliveiraDepartamento De Ciências Biológicas e Da Saúde, Laboratório De Controle de Qualidade e Bromatologia, Curso De Farmácia, Universidade Federal do Amapá, Macapá, Brazil.ORCID https://orcid.org/0000-0003-2761-3440
Eline Gomes SantosPrograma De Neurociências e Biologia Celular, Universidade Federal do Pará, Belém, Brazil.
Fabrício HolandaLaboratório De Biocatálise e Síntese Orgânica Aplicada, Curso De Química, Universidade Federal do Amapá, Macapá, Brazil.
Victor MarinhoLaboratório De Biocatálise e Síntese Orgânica Aplicada, Curso De Química, Universidade Federal do Amapá, Macapá, Brazil.
Edilene Oliveira da SilvaPrograma De Neurociências e Biologia Celular, Universidade Federal do Pará, Belém, Brazil.
José Carlos T CarvalhoDepartamento De Ciências Biológicas e Da Saúde, Laboratório De Pesquisa em Fármacos, Curso De Farmácia, Universidade Federal do Amapá, Macapá, Brazil.
Caio P FernandesDepartamento De Ciências Biológicas e Da Saúde, Laboratório De Pesquisa em Fármacos, Curso De Farmácia, Universidade Federal do Amapá, Macapá, Brazil.
Barbarella M MacchiPrograma De Pós-Graduação Em Farmacologia e Bioquímica, Universidade Federal do Pará, Belém, Brazil.
Irlon M FerreiraLaboratório De Biocatálise e Síntese Orgânica Aplicada, Curso De Química, Universidade Federal do Amapá, Macapá, Brazil.
José Luiz M NascimentoPrograma De Pós-Graduação Em Farmacologia e Bioquímica, Universidade Federal do Pará, Belém, Brazil.ORCID https://orcid.org/0000-0003-3647-9124

Funding

Conselho Nacional de Desenvolvimento Científico e tecnológico 444009/2024-8Fundação de Amparo à Pesquisa do Estado do Pará 063/2020
6 · The paper itself

Abstract

Gliomas are the most prevalent of the brain tumors, and are associated with high mortality and limited therapeutic options. This study introduces, for the first time, a silk fibroin (SF)-based microemulsion as a nanocarrier for lapachol (LP). The nanocarrier demonstrated improved stability, selectivity, and antiproliferative efficacy against glioma cells, compared to conventional pharmacological approaches. The aim of this study was to evaluate the therapeutic potential of LP and two nanostructured formulations, a lapachol nanoemulsion (LPN) and an SF-based microemulsion (LP-SF), in human (AHOL1) and rat (C6) glioma cells. Both formulations exhibited colloidal stability, with LP-SF showing sustained drug release and higher cytotoxicity (half-maximal inhibitory concentration [IC

Indexed as

Antineoplastic AgentsFibroinsGliomaNaphthoquinonesAnimalsCell Line, TumorCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug CarriersDrug LiberationDrug Screening Assays, AntitumorEmulsionsHumansParticle SizeRatsAntineoplastic AgentsDrug CarriersEmulsionsFibroinslapacholNaphthoquinonesanticancer therapycontrolled releasegliomaslapacholnanopharmaceuticalsilk fibroin

Identifiers

PMID41504026
PMCPMC12781164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.