Evidence map›Paper›PMID 41503951›Full record

ArticleChemistry & biodiversity2026

New Prenylated Isoflavonoids From Erythrina addisoniae With Anti-Neuroinflammatory Activity via Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells Pathway Suppression.

Jin-Pyo An, Gi Hyeon Seong, YunHui Che, Jorge-Eduardo Ponce-Zea, Van-Hieu Mai, Derek Tantoh Ndinteh, Joseph Tanyi Mbafor, Won Keun Oh

Abstract read
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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jin-Pyo AnResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
Gi Hyeon SeongResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
YunHui CheResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
Jorge-Eduardo Ponce-ZeaResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
Van-Hieu MaiResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
Derek Tantoh NdintehDepartment of Chemical Sciences, Center for Natural Product Research (CNPR), University of Johannesburg, Johannesburg, South Africa.
Joseph Tanyi MbaforDepartment of Organic Chemistry, Laboratory No. 3 of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
Won Keun OhResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0003-0761-3064

Funding

Basic Science Research Programs RS-2022-NR070150Basic Science Research Programs RS-2023-00218616Basic Science Research Programs through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT in KoreaNational Research Foundation of Korea
6 · The paper itself

Abstract

Recent investigations have identified prenylated isoflavonoids as major constituents of Erythrina addisoniae, yet their anti-neuroinflammatory potential remains unexplored. Through bioassay-guided isolation, two new prenylated isoflavonoids (1 and 2), along with nine known compounds (3-11), were characterized using spectroscopic methods. All isolates were tested for inhibitory effects on nitric oxide (NO) production in BV-2 microglial cells. Compounds 1, 6, 7, and 10 significantly reduced NO levels, with compounds 1 and 10 showing the strongest activity (IC

Indexed as

Anti-Inflammatory AgentsErythrinaIsoflavonesNF-kappa BAnimalsCell LineDose-Response Relationship, DrugMiceMicrogliaMolecular Docking SimulationMolecular StructureNitric OxideNitric Oxide Synthase Type IIPrenylationStructure-Activity RelationshipAnti-Inflammatory AgentsIsoflavonesNF-kappa BNitric OxideNitric Oxide Synthase Type IIErythrina addisoniaemolecular docking analysisneuroinflammationprenylated isoflavonoid

Identifiers

PMID41503951
PMCPMC13419926

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.