Evidence map›Paper›PMID 41503917›Full record

ArticleChemical research in toxicology2026

Bioaccumulation of PFOS Isomers in Transporter Proteins.

Deepak James, Jenise Z Paddayuman, Judith R Cristobal, Narasimhan Loganathan, G Ekin Atilla-Gokcumen, Diana S Aga, Angela K Wilson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Deepak JamesDepartment of Chemistry and the MSU Center for PFAS Research, Michigan State University, East Lansing, Michigan 48824, United States.ORCID 0009-0005-4657-4450
Jenise Z PaddayumanDepartment of Chemistry, University at Buffalo - The State University of New York, Buffalo, New York 14260, United States.ORCID 0009-0009-0411-2919
Judith R CristobalDepartment of Chemistry, University at Buffalo - The State University of New York, Buffalo, New York 14260, United States.
Narasimhan LoganathanDepartment of Chemistry and the MSU Center for PFAS Research, Michigan State University, East Lansing, Michigan 48824, United States.ORCID 0000-0003-0251-5430
G Ekin Atilla-GokcumenDepartment of Chemistry, University at Buffalo - The State University of New York, Buffalo, New York 14260, United States.ORCID 0000-0002-7132-3873
Diana S AgaDepartment of Chemistry, University at Buffalo - The State University of New York, Buffalo, New York 14260, United States.ORCID 0000-0001-6512-7713
Angela K WilsonDepartment of Chemistry and the MSU Center for PFAS Research, Michigan State University, East Lansing, Michigan 48824, United States.ORCID 0000-0001-9500-1628

Funding

Defining the neurotoxic and neurodevelopmental health risks of per- and polyfluoroalkyl substancesR01ES036199 · NIEHS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Diana S Aga, Gunes Ekin Atilla-Gokcumen · 2025 to 2026
$1.1M
NIEHS NIH HHS R01 ES036199
6 · The paper itself

Abstract

The many-decade use of perfluorooctanesulfonic acid (PFOS) in firefighting foams and other products has resulted in their accumulation in water sources and terrestrial environments. Long-term exposure of PFOS has been linked to detrimental effects on human health. PFOS, primarily manufactured through electrochemical fluorination (ECF), yielded both linear and branched isomers. While progress has been made in understanding the health impacts of linear PFOS exposure on human health, there is far less understanding about the toxicological effects and bioaccumulative potential of their branched isomers. In this study, the bioaccumulation potential of linear PFOS and five different branched isomers in the long-chain fatty acid (LCFA) transport protein from

Indexed as

Alkanesulfonic AcidsEscherichia coliEscherichia coli ProteinsFluorocarbonsIsomerismMolecular Dynamics SimulationAlkanesulfonic AcidsEscherichia coli ProteinsFluorocarbonsperfluorooctane sulfonic acid

Identifiers

PMID41503917
PMCPMC12820963

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.