Evidence map›Paper›PMID 41503890›Full record

ArticleChemistry & biodiversity2026

ent-Atisane Diterpenoids From Euphorbia micractina and Their Cytotoxic Activity.

Yang-Cuo Banma, Mei-Lian Wen, Ao Yang, Hao-Nan Zhang, Jiang Wu, Peng-Cheng Lin, Jian-Jun Chen

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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yang-Cuo BanmaKey Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai Nationalities University, Xining, China.
Mei-Lian WenState Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P. R. China.
Ao YangState Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P. R. China.
Hao-Nan ZhangKey Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai Nationalities University, Xining, China.
Jiang WuKey Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai Nationalities University, Xining, China.
Peng-Cheng LinKey Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai Nationalities University, Xining, China.
Jian-Jun ChenKey Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai Nationalities University, Xining, China.ORCID https://orcid.org/0000-0001-5937-5569

Funding

National Natural Science Foundation of China 22277045Qinghai Province Applied Basic Research Program 2023-ZJ-712
6 · The paper itself

Abstract

Three new ent-atisane diterpenoids (1-3) and five known ones (4-8) were obtained from the bioactive fraction of E. micractina. Their structures and absolute configurations were elucidated by a comprehensive analysis of the spectroscopic data, including high-resolution electrospray ionization mass spectrometry, infrared, nuclear magnetic resonance, X-ray crystallography, and electronic circular dichroism data. Among them, compound 1 was the first example of an ent-atisane diterpenoid with an α-oriented hydroxyl group at C-7. In addition, the cytotoxicity of all the isolated ent-atisane diterpenoids was evaluated against human cervical carcinoma, human acute promyelocytic leukemia, and human hepatoma cell lines. Compound 3 demonstrated significant cytotoxic activity against the selected cell lines with an IC

Indexed as

Antineoplastic Agents, PhytogenicDiterpenesEuphorbiaCell Line, TumorCell ProliferationCell SurvivalCrystallography, X-RayDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansModels, MolecularMolecular ConformationMolecular StructureStructure-Activity RelationshipAntineoplastic Agents, PhytogenicDiterpenescytotoxic activityent‐atisane diterpenoidEuphorbia micractina

Identifiers

PMID41503890
PMCPMC13419908

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.