ArticleChemistry & biodiversity2026
Lindenane Sesquiterpenoid Hetero- or Homo-Dimers From Sarcandra glabra and Their Anti-Neuroinflammatory Activities.
Jin-Yu Li, Yuan-Yuan Liu, Dong-Yu Wang, Han-Fei Liu, Chao Chen, Ni Zhang
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In one paragraphArticle in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
Jin-Yu LiState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, P. R. China.ORCID https://orcid.org/0000-0002-5036-8730 Yuan-Yuan LiuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, P. R. China.
Dong-Yu WangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, P. R. China.
Han-Fei LiuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, P. R. China.
Chao ChenState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, P. R. China.
Ni ZhangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang, P. R. China.
Funding
Doctoral start-up funding TCZJZ[2025]8HNatural Science Foundation of China 32160102Natural Science Foundation of China 32460112State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University GMUSKL-202536Traditional Chinese Medicine and Ethnic Medicine Science and Technology Projects of Guizhou Administration of Traditional Chinese Medicine QZYY-2025-064Traditional Chinese Medicine and Ethnic Medicine Science and Technology Projects of Guizhou Administration of Traditional Chinese Medicine QZYY-2025-081
6 · The paper itselfAbstract
Eighteen lindenane sesquiterpenoid dimers, including three previously undescribed hetero- or homo-dimers (1-3), were isolated from the whole plant of Sarcandra glabra. Their structures were elucidated by High-resolution electrospray ionization mass spectrometry, one- and two-dimensional nuclear magnetic resonance, quantum chemical calculations, and electronic circular dichroism calculations. Notably, compound 1 is a rare hetero-dimer formed by [4 + 2] cycloaddition of a eudesmane and a lindenane sesquiterpene, via C-15-C-9', C-6-C-8', and C-11-C-7' linkages. Compound 2 features a unique epoxide structural motif. All compounds were evaluated for their inhibitory effect on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in BV-2 cells. The inhibitory effects of all isolates on LPS-induced NO production in BV-2 cells were evaluated. Thirteen compounds, excluding 3, 5, 13, 15, and 16, exhibited IC
Indexed as
Anti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalSesquiterpenesAnimalsCell LineCyclooxygenase 2DimerizationDose-Response Relationship, DrugLipopolysaccharidesMiceMolecular StructureNitric OxideStructure-Activity RelationshipAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalCyclooxygenase 2LipopolysaccharidesNitric OxideSesquiterpenesanti‐neuroinflammatorychloranthaceaelindenane sesquiterpenoid dimersSarcandra glabra
Identifiers
PMID41503792
PMCPMC13419919
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