ArticleHuman vaccines & immunotherapeutics2025
Association between immune-related adverse events and prognosis in immune checkpoint inhibitor therapy: A bibliometric and visual analysis.
Article in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the gradual improvement in tumor immunotherapy, the incidence of immune-related adverse events (irAEs) has increased. However, according to current research, the relationship between irAEs and prognosis remains a contentious issue. This study used bibliometrics research to investigate hotspots and future trends on the relationship between irAEs and prognosis and to serve as a resource for researchers in this field. In the core literature database of Web of Science, the keywords immune checkpoint inhibitors(ICIs), immune-related adverse events, prognosis were used to search for the articles and reviews in the field of irAEs and prognosis. Set the time parameter to January 2007 to December 2023. Visualization analysis software CiteSpace 6.1.R6, VOSviewer1.6.18 and Carrots2 were used to conduct quantitative statistical and visual research on the author, institution, country, keyword, publication, cited literature, research status, research hotspots and development trends of the relevant research. The analytic research was based on original articles and reviews. 724 articles from 308 countries led by China(147)，the United States(131), and Japan(105) were included. The most popular tumor type is melanoma, small-cell lung cancer, and renal cell carcinoma. The focus topics in this field encompass "Myasthenia gravis," "neurotoxicity," "liver damage," "head and neck adverse events," "colitis," and "skin adverse events." This study has provided a valuable reference for future research in this field. Combination therapy, predictive biomarkers, patients' preexisting conditions, glucocorticoids, prognostic indicators, ICI rechallenge, and other topics could become research hotspots which will help us to identify useful information from complex big data and provide a basis for precise medicine for immune checkpoint inhibitor therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.