ArticleJournal of cellular and molecular medicine2026
The Effect of Multipoint Injection Strategies of BMSCs on Repairing Cartilage Defects of the Knee Joint.
Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Effect of Multipoint Injection Strategies of BMSCs on Repairing Cartilage Defects of the Knee Joint.Journal of cellular and molecular medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Bone marrow-derived mesenchymal stem cells (BMSCs) are extensively utilised in tissue engineering and regenerative medicine due to their multipotent differentiation capabilities. However, the therapeutic efficacy of BMSCs is highly dependent on the transplantation route. This study aimed to compare the efficacy of commonly used BMSCs transplantation methods and identify the optimal delivery approach for cartilage repair. Our results demonstrated that all transplantation methods could significantly suppress pro-inflammatory factors, including IL-1β, iNOS, and MMP-9, while enhancing the activity of the key antioxidant enzyme superoxide dismutase (SOD). The intra-articular injection group exhibited the most substantial anti-inflammatory and antioxidant improvements. In vivo tracking experiments revealed that BMSCs from all groups were capable of homing to the cartilage defect site at 4 weeks post-modelling. Notably, the intra-articular injection group recruited the highest number of BMSCs to the defect area. Further histological analysis indicated that the joints treated with intra-articular injection displayed superior cartilage regeneration, characterised by a smooth tissue surface and coloration closely resembling adjacent native cartilage. In conclusion, while all tested BMSCs transplantation approaches contributed to cartilage repair, intra-articular injection demonstrated the most favourable therapeutic outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.