Evidence map›Paper›PMID 41503734›Full record

ArticleChemistry & biodiversity2026

Mitochondria-Targeted TPP-Meroditerpenes Based on Quinopimaric and Dehydroquinopimaric Acids: Synthesis and Evaluation of Cytotoxicity and Antibacterial Activity.

Anastasiya M Smyslova, Andrey V Nemtarev, Alexandra D Voloshina, Anna P Lubina, Alexei B Dobrynin, Igor A Litvinov, Vladimir F Mironov

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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Anastasiya M SmyslovaKazan (Volga Region) Federal University, Kazan, Russia.
Andrey V NemtarevArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia.ORCID https://orcid.org/0000-0001-8478-2705
Alexandra D VoloshinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia.
Anna P LubinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia.
Alexei B DobryninArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia.
Igor A LitvinovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia.
Vladimir F MironovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia.

Funding

Kazan Federal University Strategic Academic Leadership Program PRIORITY-2030
6 · The paper itself

Abstract

A convenient approach to the synthesis of quaternary phosphonium salts, bearing a diterpenoid fragment is proposed. This highly regioselective synthesis is based on the reaction of quinopimaric and dehydroquinopimaric acids with P─H-phosphonium salts. The structures of obtained quaternary phosphonium salts based on quinopimaric and dehydroquinopimaric acid were confirmed by NMR and IR spectroscopy, mass spectrometry, and XRD. Compounds possess both antibacterial activity and in vitro cytotoxicity against human cancer cell lines. Selectivity of cytotoxic action depends on substituents in the aromatic moieties of phosphonium salts. Also, phosphonium derivatives of quinopimaric acid, possessing a hydroxyvinyl fragment bound directly to the phosphorus atom, show a higher cytotoxicity than dehydroquinopimaric acid phosphonium derivatives. Highest cytotoxicity is for the phosphonium derivatives of quinopimaric acid, containing 4-methoxyphenyl substituents (IC

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsDiterpenesMitochondriaApoptosisCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorGram-Positive BacteriaHumansMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsAntineoplastic AgentsDiterpenesanticancer activitydehydroquinopimaric aciddrug discoveryphosphonium saltsquinonesquinopimaric acid

Identifiers

PMID41503734
PMCPMC13419961

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.