ArticleChemistry & biodiversity2026
An Expedient Synthesis of 2-Acylthiazoles and 2-Acyl-4-methyl-5-acetylthiazoles Using α-Ketothioamides as Potential Acetylcholinesterase Inhibitors.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
Herein, report a simple and efficient strategy for the synthesis of 1,3 thiazole from the easily accessible α-ketothioamides. The thioamide synthetic equivalents react smoothly with bromoacetals and 3-chloropentane-2,4-dione to afford a series of substituted thiazoles 4a-l and 6a-l, demonstrating a high degree of thioamide functionalization. The reported procedure stands up due to the rapid reaction time with metal-free mild conditions rendering it an attractive option for thiazole synthesis. The resulting compounds were evaluated for their neuroprotective effects through in vitro acetylcholinesterase (AChE) inhibitory activity. Among the synthesized molecules, compound 6j exhibited the most significant inhibitory effect, surpassing the standard drug rivastigmine in activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.