Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors.
Courtney A BroedlowDepartment of Pediatrics, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Angela McGaughDepartment of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Tiffany R GlynnDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-0305-1976
Emily M CherenackDepartment of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA.ORCID 0000-0002-8762-2050
Charlene MillerDepartment of Pediatrics, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Maria L AlcaideDivision of Infectious Diseases, Department of Medicine, Miller School of Medicine, University of Miami, Florida, USA.
Jose A BauermeisterDepartment of Family and Community Health, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-9276-2306
Christian GrovDepartment of Community Health and Social Sciences, Graduate School of Public Health and Health Policy, City University of New York, New York, New York, USA.ORCID 0000-0001-6871-3531
Robert ParisiAIDS Healthcare Foundation, Ft Lauderdale, Florida, USA.
Darling MartinezAIDS Healthcare Foundation, Ft Lauderdale, Florida, USA.
Adam W CarricoDepartment of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Nichole R KlattDepartment of Pediatrics, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Jennifer A ManuzakDepartment of Pediatrics, Miller School of Medicine, University of Miami, Miami, Florida, USA.ORCID 0000-0002-0079-2306
Funding
Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Rana Chakraborty · 2007 to 2026
$33.8M
PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
Leveraging mHealth to develop syndemic-based behavioral medicine HIV prevention for the emergency department to reach people who use drugsK23DA060719 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI Tiffany Rose Glynn · 2024 to 2026
$599k
Syndemics, the microbiome, and mucosal inflammation involved in HIV acquisitionF32AI162229 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CHERENACK, EMILY MELLISSA · 2021 to 2023
$211k
AIDS Healthcare FoundationIDSA GERMNIAID NIH HHS F32 AI162229NIAID NIH HHS P30 AI073961NIAID NIH HHS T32 AI007433NIDA NIH HHS K23 DA060719NIDA NIH HHS L60 DA059128NIH HHS P51 OD011104University of Miami Center for AIDS Research 1F32AI162229University of Miami Center for AIDS Research K23DA060719University of Miami Center for AIDS Research L60DA059128University of Miami Center for AIDS Research P30AI073961University of Miami Center for AIDS Research T32AI007433
6 · The paper itself
Abstract
backgroundReceptive condomless anal sex (CAS) associates with elevated rectal inflammation and mucosal injury, increasing HIV acquisition risk. Although douching may amplify rectal inflammation and alter microbial communities, this has not been well characterized in sexual minority men (SMM).
methodsNinety-two SMM (median age, 34.6 years) who were HIV negative and reported receptive CAS provided rectal swabs during sexually transmitted infection (STI) clinic visits. Associations among rectal douching, rectal cytokine/chemokine levels, and microbial communities, evaluated via immunoassay and 16S rRNA gene sequencing, respectively, were assessed.
resultsWhen compared with nondouching SMM (n = 27), SMM who douched (n = 64) reported more receptive CAS partners and displayed elevations in rectal cytokine/chemokines linked to immune activation and inflammation. Lower microbial richness, evenness, and Shannon diversity in SMM who reported douching were observed. Significant associations were identified between microbial alpha diversity metrics and rectal chemokine/cytokine levels. Finally, significant correlations were observed between rectal cytokine/chemokine levels and individual microbial genera.
conclusionsAmong SMM engaging in receptive CAS, douching may identify those with amplified biobehavioral HIV and STI risk. Elucidating the mechanisms whereby douching dysregulates rectal immune function and alters rectal microbial communities could yield targets for biomedical approaches to optimize HIV/STI prevention in SMM during receptive CAS.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Douching Is Associated With Dysregulated Rectal Mucosal Immunity in Sexual Minority Men. · full record | OpenQuestion