ArticleThe Lancet regional health. Western Pacific2026
Interaction between physical activity and deficit-based frailty on all-cause mortality in older adults: a prospective study of five population-based cohorts.
Article in The Lancet regional health. Western Pacific, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Associations of Physical Activity With Mortality Across Cardiovascular-Kidney-Metabolic Syndrome Stages: Evidence From NHANES 1999 to 2018.Journal of the American Heart Association · 2026Article
- The joint association of intrinsic capacity and physical activity with cardiovascular risk in older adults: evidence from four longitudinal cohorts.BMC geriatrics · 2026Article
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Authors and funding
18 authors.
Funding
Abstract
Background: Whether leisure-time physical activity modifies the association between frailty and mortality in older adults is unclear. Methods: We analyzed the interactions between physical activity and frailty status on all-cause mortality risk using Cox proportional hazards models across five nationally representative cohorts: Survey of Health, Ageing and Retirement in Europe (56,555 participants, median follow-up 6.5 years), China Health and Retirement Longitudinal Study (12,271 participants, 9.0 years); Health and Retirement Study (13,729 participants, 11.9 years); English Longitudinal Study of Ageing (9100 participants, 9.8 years); and Mexican Health and Aging Study (11,262 participants, 19.3 years). Frailty status was classified as robust, prefrail, and frail based on deficit accumulation models, including common disease, functional, locomotor, sensory, mental, and cognitive deficit. Physical activity was classified as regular (meeting World Health Organization recommendations) or inactive. Findings: Across five cohorts (median age 58.0-65.0 years), physical activity consistently interacted with frailty on all-cause mortality (all P Interpretation: Consistent findings across five cohorts demonstrated that regular physical activity mitigates frailty-associated mortality, and frail adults might gain more survival benefits from regular activity than robust adults. Funding: The Noncommunicable Chronic Diseases-National Science and Technology Major Project, the National Natural Science Foundation of China, the National Key R&D Program of China, the "Shu-Guang Scholar Programme" from Shanghai Municipal Education Commission, the "Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support" from Shanghai Jiao Tong University School of Medicine, and the Innovative Research Team of High-level Local Universities in Shanghai.
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Registered trials
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