ArticleIEEE journal of translational engineering in health and medicine2026
A Comprehensive Study of Uterine Muscle Activity During the Third Trimester: Comparison of Singleton and Multiple Gestations.
Article in IEEE journal of translational engineering in health and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Electrohysterography for Uterine Contractility Monitoring: Measurement Principles, Clinical Evidence, and Reporting Recommendations.Sensors (Basel, Switzerland) · 2026Review
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10 authors.
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Abstract
objectiveElectrohysterography (EHG) has been shown to provide valuable information for assessing preterm birth risk. However, few studies have focused on multiple gestations (MG), a well-known risk factor for preterm birth. This study aimed to comprehensively characterize and compare uterine EHG signals between singleton (SG) and MG pregnancies during the third trimester.
methodThis prospective cohort study analyzed 383 EHG recordings from 61 SG and 92 MG women during the third trimester. A whole-window approach was used to extract four key EHG features: peak-to-peak amplitude (PPA), Kurtosis of the Hilbert Envelope (KHE), median frequency (MDF) and sample entropy (SampEn). Generalized additive models (GAM) were applied to evaluate temporal trends across gestational age (GA) and gestation type (SG and MG).
resultsIn SG pregnancies, PPA and KHE progressively increased, with a significant rise in KHE at labour. MDF remained stable until labour, while SampEn gradually declined, especially at term. MG pregnancies showed similar but less pronounced trends: MG exhibited a notably earlier activation of uterine activity than SG before 32 weeks of gestation (WoG), and a slowing-down electrophysiological progression beyond 32 WoG, resulting in similar characteristics with no significant differences.
conclusionThese findings provide electrophysiological evidence suggesting that MG pregnancies may enter a labour-preparatory state earlier, potentially increasing the PTB risk, while the later convergence of EHG features may indicate compensatory mechanisms to delay labour. This work integrates EHG signal analysis with clinical obstetric care, offering valuable insights for clinical management and early PTB risk assessment in MG pregnancies.
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