ArticleHealth science reports2026
Efficacy, Effectiveness, and Safety of Treatment Regimens for Histoplasmosis and Tuberculosis Coinfection in Patients With Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: A Systematic Review With Meta-Analysis Protocol.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: While previous publications have briefly pointed out a few alternative therapeutic interventions for the treatment of histoplasmosis and tuberculosis coinfections in patients with Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS), there are no reviews evaluating the efficacy, effectiveness, and safety of different regimens. Thus, this protocol outlines the approach for systematically reviewing and synthesizing the existing literature regarding the efficacy, effectiveness, and safety of different regimens for histoplasmosis and tuberculosis coinfection treatment in patients with HIV/AIDS. Methods: A systematic search will be conducted using PubMed, Embase, and Latin American and Caribbean Health Sciences Literature (LILACS) databases. Studies will be selected in two distinct stages, and data from selected studies will be extracted. Risk of bias will be assessed using the RoB 2, ROBINS-I, NOS, and JBI tools, depending on the type of study. Finally, the strength of the body of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. Conclusions: The findings of this review may positively impact public health, stimulating the implementation of evidence-based practices and guiding the adoption of specific treatment protocols for patients with HIV/AIDS coinfected with histoplasmosis and tuberculosis in endemic regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.