Evidence map›Paper›PMID 41503489›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Microbial Ecological Signatures Predict Pathogen Emergence and Multidrug Resistance in Cystic Fibrosis Airways up to a Year in Advance.

Thomas R Goddard, Jessica Ap Carlson-Jones, Morton Judith, Chee Y Ooi, Tai Andrew, Morgyn S Warner, Wong John, Ieuan Es Evans, Emily Hopkins, Jonathan R Iredell and 32 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Thomas R GoddardDepartment of Respiratory and Sleep Medicine, Women's and Children's Hospital, 72 King William Rd, Adelaide, SA, 5042, Australia.ORCID 0000-0002-7062-843X
Jessica Ap Carlson-JonesFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0002-2862-0338
Morton JudithDepartment of Thoracic Medicine, The Royal Adelaide Hospital, 1 Port Road, Adelaide, SA, 5000, Australia.ORCID 0000-0002-1715-5573
Chee Y OoiDiscipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW Medicine and Health, University of New South Wales, 55 Botany Street, Randwick, NSW, 2031, Australia.ORCID 0000-0001-7111-0926
Tai AndrewDepartment of Respiratory and Sleep Medicine, Women's and Children's Hospital, 72 King William Rd, Adelaide, SA, 5006, Australia.ORCID 0000-0001-9240-5416
Morgyn S WarnerMicrobiology & Infectious Diseases, SA Pathology, 1 Port Road, Adelaide, SA, 5000, Australia.ORCID 0000-0002-4053-1610
Wong JohnDepartment of Respiratory and Sleep Medicine, Women's and Children's Hospital, 72 King William Rd, Adelaide, SA, 5006, Australia.
Ieuan Es EvansAdult Cystic Fibrosis Centre, The Prince Charles Hospital, 627 Rode Road, Brisbane, QLD, 4032, Australia.ORCID 0000-0002-9669-0805
Emily HopkinsDepartment of Thoracic Medicine, The Royal Adelaide Hospital, 1 Port Road, Adelaide, SA, 5000, Australia.ORCID 0000-0003-0736-4766
Jonathan R IredellPhage Australia, Westmead Institute for Medical Research, 176 Hawkesbury Rd, Sydney, NSW, 2145, Australia.ORCID 0000-0003-2469-7060
Hubertus Pa JersmannDepartment of Respiratory and Sleep Medicine, Women's and Children's Hospital, 72 King William Rd, Adelaide, SA, 5006, Australia.ORCID 0000-0003-1763-2736
Katrine L WhitesonCharle Dunlop School of Biological Sciences, University of California, Irvine, 3236 McGaugh Hall, Irvine, CA, 92697, USA.ORCID 0000-0002-5423-6014
George BourasThe Department of Surgery - Otolaryngology Head and Neck Surgery, University of Adelaide and the Basil Hetzel Institute for Translational Health Research, Central Adelaide Local Health Network, Adelaide, SA, 5000, Australia.ORCID 0000-0002-5885-4186
Michael P DoaneFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0001-9820-2193
Nicholas W FalkFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0003-2180-7359
Renee GreenFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0009-0001-8287-1955
Susanna R GrigsonFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0003-4738-3451
Vijini MallawaarachchiFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0002-2651-8719
Belinda MartinFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0003-4696-1694
Michael J RoachCollege of Medicine and Public Health, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0003-1488-5148
Feargal J RyanCollege of Medicine and Public Health, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0002-1565-4598
Anita TarasenkoFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0009-0003-4283-2374
Bhavya PapudeshiFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0001-5359-3100
Barbara DrigoSchool of Agriculture, Food and Wine, Adelaide University, 31 Hartley Grove, Urrbrae, SA, 5064, Australia.ORCID 0000-0002-3301-0470
Sarah K GilesFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0002-4395-060X
Clarice M HarkerCollege of Medicine and Public Health, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0009-0008-6802-6799
Ryan D HesseFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0001-9366-5631
Riley J HodgsonCollege of Science and Engineering, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0002-8043-2473
Art HussnainSchool of Agriculture, Food and Wine, Adelaide University, Plant Genomics Centre, Hartley Grove, Urrbrae, SA, 5064, Australia.ORCID 0009-0000-6513-3638
Abbey HuttonFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0002-2474-1327
Laura K InglisFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0001-7919-8563
Christopher KeneallyEnvironment Institute, Adelaide University, North Terrace, Adelaide, SA, 5005, Australia.ORCID 0000-0001-7261-6259
Emma N KerrFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0002-1446-4282
Craig LiddicoatCollege of Science and Engineering, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0002-4812-7524
Shawn D PeddleCollege of Science and Engineering, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0003-3464-3058
Carl D WatsonCollege of Science and Engineering, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0002-7721-2162
Qi YangCSIRO Agriculture & Food, CSIRO, 40 Waite Rd, Urrbrae, SA, 5064, Australia.ORCID 0000-0002-4930-9661
Przemysław DecewiczLaboratory of Applied Microbial Ecology, Institute of Microbiology, Faculty of Biology, University of Warsaw, I. Miecznikowa 1, Warsaw, 02-096, Poland.ORCID 0000-0002-5621-7124
Peter G SpeckCollege of Science and Engineering, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0001-9087-258X
James G MitchellFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0002-8445-0935
Elizabeth A DinsdaleFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0002-2177-203X
Robert A EdwardsFlinders Accelerator for Microbiome Exploration, Flinders University, Sturt Road, Bedford Park, SA, 5042, Australia.ORCID 0000-0001-8383-8949

Funding

Computational and Experimental Resources for Virome Analysis in Inflammatory Bowel Disease (CERVAID)RC2DK116713 · NIDDK · WASHINGTON UNIVERSITY · PI WANG, DAVID · 2019 to 2023
$8.9M
NIDDK NIH HHS RC2 DK116713
6 · The paper itself

Abstract

Chronic infections in cystic fibrosis (CF) emerge from gradual ecological transitions in the airway microbiome, yet early predictive markers remain poorly defined. We developed a new autoencoder-based framework that outperforms read-based or metagenome-assembled genome-based analyses at capturing the continuum from health-associated commensals to pathogen-dominated, antibiotic-tolerant communities. This improvement is achieved by integrating taxonomic and functional data from 127 sputum and bronchoalveolar lavage metagenomes from 64 people with CF into latent "Clusters of Phylogeny and Functions" (COPFs). Coupled with gradient-boosted random forests, COPFs predicted

Identifiers

PMID41503489
PMCPMC12772665

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.