Evidence map›Paper›PMID 41503486›Full record

ArticlemedRxiv : the preprint server for health sciences2025

The Global Parkinson's Disease Genetics (GP2) Genome Browser.

Zih-Hua Fang, Riley H Grant, Dan Vitale, Carlos F Hernandez, Samantha Hong, Hampton L Leonard, Mary B Makarious, Lara M Lange, Matthew Solomonson, Peter Heutink and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Zih-Hua FangDataTecnica, Washington, DC, USA.ORCID 0000-0002-0225-8772
Riley H GrantProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Dan VitaleDataTecnica, Washington, DC, USA.
Carlos F HernandezUniversidad del Desarrollo, Centro de Genética y Genómica, Facultad de Medicina Clínica Alemana, Santiago 7610658, Chile.
Samantha HongCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Hampton L LeonardDataTecnica, Washington, DC, USA.ORCID 0000-0003-2390-8110
Mary B MakariousDataTecnica, Washington, DC, USA.ORCID 0000-0002-7978-1051
Lara M LangeLaboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA.ORCID 0000-0002-7162-9821
Matthew SolomonsonProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-5344-9026
Peter HeutinkGlobal Parkinson's Genetics Program, MD, USA.ORCID 0000-0001-5218-1737
Allison A DilliottParkinson's Foundation, New York, NY, USA.ORCID 0000-0003-3863-9304
Kamalini Ghosh GalvelisParkinson's Foundation, New York, NY, USA.ORCID 0009-0000-4178-0777
Mike A NallsDataTecnica, Washington, DC, USA.
Andrew B SingletonGlobal Parkinson's Genetics Program, MD, USA.ORCID 0000-0001-5606-700X
Cornelis BlauwendraatGlobal Parkinson's Genetics Program, MD, USA.ORCID 0000-0001-9358-8111
Global Parkinson’s Genetics Program (GP2)

Funding

STRIDESOT2OD027852 · OD · FOUR POINTS TECHNOLOGY, LLC · PI Joel A Lipkin · 2018 to 2026
$255.6M
STRIDES OT2OD027060 · OD · CARAHSOFT TECHNOLOGY CORPORATION · PI Terry Drinkwine · 2018 to 2026
$134.1M
NIH STRIDES - Azure and Associated Services and Training.OT2OD032100 · OD · DELL FEDERAL SYSTEMS L.P. · PI Amy K HammondOdwyer, Erum Siddiqui · 2021 to 2026
$62.2M
THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITEU24AG041689 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LI-SAN WANG · 2012 to 2026
$42.3M
Genome wide SNP analysis in Parkinson's diseaseZ01AG000949 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW B · 2006 to 2008
$2.6M
Intramural NIH HHS Z01 AG000949NIA NIH HHS U24 AG041689NIH HHS OT2 OD027060NIH HHS OT2 OD027852NIH HHS OT2 OD032100
6 · The paper itself

Abstract

Background: Large-scale sequencing initiatives have generated extensive genomic resources essential for variant interpretation, yet their effective use often requires bioinformatics expertise. To support identification of Parkinson's disease (PD) risk and disease-causing variants, we developed an open-access, summary-level genomic data browser. Methods: We performed uniform joint variant calling to harmonize whole-genome sequencing (WGS) data from AMP-PD Release 4, GP2 Data Releases, and additional controls from the Alzheimer's Disease Sequencing Project. Clinical exome sequencing (CES) data from GP2 Release 8 was also included. Results: The integrated dataset includes 31,665 WGS and 9,559 CES samples, spanning eleven ancestries and over 300 million variants. Conclusion: The GP2 Genome Browser is a lightweight, flexible platform providing intuitive gene- and variant-level summaries with ancestry-stratified allele frequencies and functional annotations. It is open source and freely accessible at https://gp2.broadinstitute.org, enabling broad access to PD genomic data and supporting global research efforts.

Indexed as

browsergeneticsParkinson’s diseasesequencing

Identifiers

PMID41503486
PMCPMC12772649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.