Evidence map›Paper›PMID 41503457›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Genome-Wide Association Study for Glucocorticoid-Induced Ocular Hypertension.

Jyoti Lama, Renee Liu, Alicia Huerta-Chagoya, Ashley Li, Katie Huynh, Lynn K Stanwyck, Samuel Han, Yan Zhao, Weilin Chan, Liyin Chen and 16 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Jyoti LamaDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Renee LiuDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Alicia Huerta-ChagoyaProgram in Metabolism Broad Institute of MIT and Harvard, Cambridge, MA.
Ashley LiDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Katie HuynhDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Lynn K StanwyckDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Samuel HanDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Yan ZhaoDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Weilin ChanDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Liyin ChenDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Ananya MukundanDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Da MengDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Janine Y YangDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Gayatri SusarlaDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Delia SangDelia N. Sang, MD, Brookline, MA.
George N PapaliodisDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Lucy Q ShenDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Elizabeth RossinDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Christine ElkinsRetina Health Center, Fort Myers, Florida.
Irma BenavidesRetina Health Center, Fort Myers, Florida.
Hussein WafapoorRetina Health Center, Fort Myers, Florida.
Antonio CutinoAlimera Sciences Inc., Alpharetta, GA.
Janey L WiggsDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Alexander M EatonRetina Health Center, Fort Myers, Florida.
Ayellet V SegrèDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.ORCID 0000-0001-6806-5845
Lucia SobrinDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.

Funding

P30 Core Grant for Vision ResearchP30EY014104 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Janey L Wiggs · 2002 to 2026
$15.1M
Elucidating novel mechanisms for glucocorticoid-induced ocular hypertensionR01EY031027 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI SOBRIN, LUCIA · 2020 to 2024
$3.4M
The development of visual behavior in infancyR01EY030127 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LISA M OAKES · 2019 to 2026
$3.3M
NEI NIH HHS P30 EY014104NEI NIH HHS R01 EY030127NEI NIH HHS R01 EY031027
6 · The paper itself

Abstract

Purpose: To identify genetic variants associated with glucocorticoid (GC)-induced intraocular pressure (IOP) change using genome-wide association study (GWAS) and whole exome sequencing (WES) analyses. Methods: 530 participants from the Fluocinolone Acetonide in Diabetic Macular Edema (FAME) trials were analyzed, with replication performed in an independent cohort of 588 participants from the Mass Eye and Ear/Retina Health Center (MEE/RHC). All participants were exposed to GC, primarily via intravitreal injection. IOP was measured at baseline and serially within 6 months following GC exposure. GWAS and rare variant gene burden analyses were applied, adjusting for covariates. Results: Genetic associations for maximal IOP change within 6 months after GC exposure were evaluated. For the primary outcome across all ancestries in FAME, one variant, rs13425173 within the Conclusion: We have identified genome-wide significant common variants associated with GC-IOP change, as well as genes and rare variants that may influence GC-induced IOP change.

Indexed as

corticosteroidgenome-wide association studyglucocorticoidintraocular pressuresteroidsteroid-responder

Identifiers

PMID41503457
PMCPMC12772669

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.