ArticleNeuroimage. Reports2026
The critical role of the basal ganglia in post-stroke fatigue: A pilot study.
Article in Neuroimage. Reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Towards a domain-general mechanistic model of fatigue: application to Functional Neurological Disorder.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Poststroke Fatigue: An Overlooked Barrier to Functional Recovery.Journal of the American Heart Association · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This pilot study aimed to explore the neural mechanisms underlying cognitive fatigue (CF) in stroke survivors, with a focus on the role of basal ganglia damage. Sixteen participants were recruited, including six stroke survivors with basal ganglia lesions (BG+), four with lesions elsewhere in the brain (BG-), and six healthy controls (HC). Participants underwent neuropsychological assessments and an fMRI fatigue induction task, where CF was induced using a modified letter-comparison task under individually titrated response deadlines. CF was assessed using the Visual Analog Scale of Fatigue (VAS-F), and fMRI data were analyzed to identify task-evoked activation within the fatigue network. Stroke survivors reported higher levels of CF compared to healthy controls, with the BG+ group exhibiting the highest fatigue levels and the greatest increase in fatigue over time. The BG+ group also demonstrated the most pronounced disparity in reaction times between short and long response deadlines. Functional neuroimaging revealed that CF ratings correlated with task-evoked activation in the fatigue network, but only in the BG- group. Our findings suggest that while stroke presence generally may increase CF, damage specifically involving the basal ganglia accelerates its accrual. Moreover, the ability to engage the fatigue network may mitigate fatigue, as observed in the BG- group. These results underscore the importance of basal ganglia in understanding CF and highlight the need for future research in this area.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.