ArticleEcology and evolution2026
New Insights Into the Evolution of Immune Adaptors in Murid Rodents.
Article in Ecology and evolution, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- New Insights Into the Evolution of Immune Adaptors in Murid Rodents.Ecology and evolution · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolutionary dynamics of immune adaptors in wildlife remain poorly understood, despite their critical role in host-pathogen interactions. In this study, we investigated the molecular evolution of five TIR domain-containing adaptors (MAL, MyD88, SARM, TRAM, and TRIF) in murid rodents across both interspecific and population levels to provide an integrative view of their evolutionary trajectories. Our analyses demonstrate that these adaptors are predominantly under purifying selection in murids, yet contain specific positively selected sites in MAL and MyD88, indicating localized adaptive fine-tuning. These positively selected amino acid sites exhibited substantial genetic divergence among murid species. Within populations, we observed reduced genetic diversity in the adaptor genes compared with noncoding regions across the whole genome in both
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Registered trials
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