Evidence map›Paper›PMID 41503365›Full record

ArticleJournal of biomedical optics2026

Improved imaging interfaces on a co-registered ultrasound and optical microscopy multiscale system.

Jonathan Hale, Nathan Cudworth, Renata Farrell, Aarushi Bhargava, Kevin W Eliceiri, Ivan Rosado-Mendez

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jonathan HaleUniversity of Wisconsin-Madison, School of Medicine and Public Health, Department of Medical Physics, Madison, Wisconsin, United States.ORCID https://orcid.org/0000-0002-4266-9947
Nathan CudworthUniversity of Wisconsin-Madison, School of Medicine and Public Health, Department of Medical Physics, Madison, Wisconsin, United States.
Renata FarrellUniversity of Wisconsin-Madison, College of Engineering, Department of Biomedical Engineering, Madison, Wisconsin, United States.ORCID https://orcid.org/0009-0004-5057-0906
Aarushi BhargavaUniversity of Wisconsin-Madison, School of Medicine and Public Health, Department of Medical Physics, Madison, Wisconsin, United States.ORCID https://orcid.org/0000-0003-0340-2681
Kevin W EliceiriUniversity of Wisconsin-Madison, School of Medicine and Public Health, Department of Medical Physics, Madison, Wisconsin, United States.ORCID https://orcid.org/0000-0001-8678-670X
Ivan Rosado-MendezUniversity of Wisconsin-Madison, School of Medicine and Public Health, Department of Medical Physics, Madison, Wisconsin, United States.ORCID https://orcid.org/0000-0003-0778-1260

Funding

U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
The Center for Label-free Imagingand Multiscale Biophotonics (CLIMB)P41EB031772 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Stephen A Boppart · 2022 to 2026
$7.6M
NCI NIH HHS T32 CA009206NIBIB NIH HHS P41 EB031772
6 · The paper itself

Abstract

Significance: Integrating ultrasound (US) with multiphoton microscopy (MPM) enables comprehensive tissue characterization by combining contrast mechanisms across spatial scales. However, prior implementations suffer from degraded US image quality at the glass optical window arising from off-axis acoustic noise (clutter). Aim: We aimed to reduce clutter near the optical window without compromising the MPM image quality using different optical window materials combined with different ultrasound beamforming techniques. Approach: Clutter in B-mode images was measured for glass and several optically clear polymer films using physically or synthetically focused US beamforming with varied focal configurations ( Results: Candidate materials included polymethyl pentene (PMP), cyclin olefin copolymer (COC), polycarbonate (PC), polyethylene terephthalate, polymethyl methacrylate, and an Ibidi Conclusions: COC or Ibidi

Indexed as

Image Processing, Computer-AssistedMicroscopy, Fluorescence, MultiphotonAnimalsCollagenPolymersRatsTendonsUltrasonographyCollagenPolymersacoustic cluttercollagenmultimodalmultiscalenonlinear opticssecond-harmonic generationultrasound

Identifiers

PMID41503365
PMCPMC12771023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.