Evidence map›Paper›PMID 41503363›Full record

ArticleFrontiers in immunology2025

Xuebijing injection mitigates instant blood-mediated inflammatory reaction and enhances intrahepatic islet transplantation via target NF-κB pathway.

Yixiang Zhan, Yingbo Wang, Boya Zhang, Yijun Zhang, Rui Liang, Jiuxia Yang, Tengli Liu, Xiaoyan Hu, Tianyi You, Na Liu and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Yixiang ZhanResearch Institute of Transplant Medicine, Organ Transplant Center, National Health Commission (NHC) Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Yingbo WangThe First Central Clinical College, Tianjin Medical University, Tianjin, China.
Boya ZhangResearch Institute of Transplant Medicine, Organ Transplant Center, National Health Commission (NHC) Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Yijun ZhangThe First Central Clinical College, Tianjin Medical University, Tianjin, China.
Rui LiangResearch Institute of Transplant Medicine, Organ Transplant Center, National Health Commission (NHC) Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Jiuxia YangResearch Institute of Transplant Medicine, Organ Transplant Center, National Health Commission (NHC) Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Tengli LiuResearch Institute of Transplant Medicine, Organ Transplant Center, National Health Commission (NHC) Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Xiaoyan HuResearch Institute of Transplant Medicine, Organ Transplant Center, National Health Commission (NHC) Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Tianyi YouResearch Institute of Transplant Medicine, Organ Transplant Center, National Health Commission (NHC) Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Na LiuResearch Institute of Transplant Medicine, Organ Transplant Center, National Health Commission (NHC) Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Yuqi ChenThe First Central Clinical College, Tianjin Medical University, Tianjin, China.
Qing LiuThe First Central Clinical College, Tianjin Medical University, Tianjin, China.
Tingsheng JiangThe First Central Clinical College, Tianjin Medical University, Tianjin, China.
Zhaoce LiuResearch Institute of Transplant Medicine, Organ Transplant Center, National Health Commission (NHC) Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Xiangheng CaiResearch Institute of Transplant Medicine, Organ Transplant Center, National Health Commission (NHC) Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Runnan YangThe First Central Clinical College, Tianjin Medical University, Tianjin, China.
Yingyi QiThe First Central Clinical College, Tianjin Medical University, Tianjin, China.
Peng SunResearch Institute of Transplant Medicine, Organ Transplant Center, National Health Commission (NHC) Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Jiaqi ZouResearch Institute of Transplant Medicine, Organ Transplant Center, National Health Commission (NHC) Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Xuejie DingResearch Institute of Transplant Medicine, Organ Transplant Center, National Health Commission (NHC) Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Zhuzeng YinFaculty of Hepato-Pancreato-Biliary Surgery, The First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
Shusen WangResearch Institute of Transplant Medicine, Organ Transplant Center, National Health Commission (NHC) Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Instant blood-mediated inflammatory reaction (IBMIR) is a major obstacle in clinical islet transplantation, leading to islet apoptosis and dysfunction due to inflammatory reaction. Xuebijing (XBJ), a traditional Chinese medicine, has been extensively used in the treatment of systemic inflammatory conditions and achieved remarkable effect. Giving these properties, XBJ holds promise in improving the outcomes of intrahepatic islet transplantation through inhibiting IBMIR. Methods: The xenogeneic islet transplantation model was employed to evaluate the inhibitory effects of XBJ on IBMIR, while the syngeneic transplantation model was used to confirm that XBJ improves the long-term outcomes of intrahepatic islet transplantation through IBMIR suppression. In addition, studies were conducted under inflammatory conditions to demonstrate the protective effects of XBJ on islets in vitro, specifically its ability to preserve islet viability and function in an inflammatory environment. Results: Discussion: This study provides the evidence that XBJ improves islet transplantation outcomes through dual mechanisms targeting the IBMIR. As an already approved drug, XBJ presents a promising and readily translatable adjunctive therapy for clinical intrahepatic islet transplantation.

Indexed as

Diabetes Mellitus, ExperimentalDrugs, Chinese HerbalInflammationIslets of Langerhans TransplantationNF-kappa BAnimalsApoptosisGraft SurvivalIslets of LangerhansMaleMiceMice, Inbred C57BLSignal TransductionDrugs, Chinese HerbalNF-kappa BXuebijingdiabetesIBMIRislet transplantationNF-κB pathwayXuebijing injection

Identifiers

PMID41503363
PMCPMC12771108

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.