A Rare Case of Pilomatricoma of the Male Breast Mimicking Breast Carcinoma: A Diagnostic Challenge.

Elena Wen Xuan Tay, Naman Siddique, Olga Shmuilovich, Anat Kornecki, Mariamma G Joseph

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Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Elena Wen Xuan TayDepartment of Health Sciences, Western University, London, CAN.

Naman SiddiqueDepartment of Medical Imaging, London Health Sciences Centre/Western University, London, CAN.

Olga ShmuilovichDepartment of Medical Imaging, St. Joseph's Health Centre/Western University, London, CAN.

Anat KorneckiDepartment of Medical Imaging, St. Joseph's Health Centre/Western University, London, CAN.

Mariamma G JosephDepartment of Pathology and Laboratory Medicine, London Health Sciences Centre/Western University, London, CAN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pilomatricoma is a benign skin adnexal tumour often seen in children and young adults. We report a rare case of pilomatricoma of the breast in a 65-year-old male patient who presented with a palpable breast lump. Initial clinical and radiological evaluation suggested primary breast carcinoma. Histopathological examination showed classic features of a benign pilomatricoma with basaloid matrical cells, shadow (ghost) cells, and a foreign body giant cell reaction. There was only minimal microcalcification present. There was strong and diffuse nuclear and cytoplasmic staining of basaloid matrical cells for beta-catenin. This case highlights the diagnostic challenges posed by uncommon breast masses and emphasises the need for histologic confirmation by a tissue biopsy. Pathologists and clinicians should be aware that although pilomatricoma is a common skin adnexal tumour in the head and neck region, it can rarely present as a breast lump. Recognising this uncommon presentation is essential to avoid misdiagnosis and ensure appropriate management.

Indexed as

benign skin adnexal tumorsbeta-catenin ctnnb1diagnostic challengesmale breast tumorpathologypilomatricomaradiology

Identifiers

PMID41503333

DOI10.7759/cureus.98654

PMCPMC12774551

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