ReviewCureus2025
Postoperative Bleeding Complications Associated With Dental Implant Placement in Patients Receiving Antithrombotic Therapy: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review and meta-analysis aimed to quantify the risk and clinical management of postoperative bleeding complications associated with dental implant surgery in adults on antithrombotic therapy. Comprehensive searches of PubMed, Cochrane CENTRAL, Embase, and Google Scholar (2011-2025) identified 15 observational studies comprising 3,101 participants and ∼2,300 implant placements, involving regimens of vitamin K antagonists, direct oral anticoagulants, and antiplatelet agents. The eligible studies included prospective and retrospective cohorts, cross-sectional and case-control designs, and the risk of bias was assessed using the ROBINS-I tool. A primary random-effects meta-analysis was done on eight studies, and it revealed a significantly elevated risk of postoperative bleeding among antithrombotic therapy recipients versus controls (pooled risk ratio, RR = 4.47; 95% CI: 2.35-8.51; P < 0.00001), albeit with low-to-moderate statistical heterogeneity (I² = 28%). Sensitivity analysis of restricted to low risk-of-bias studies (n = 4) showed attenuation of the pooled effect, yielding a non-significant association (RR = 1.61; 95% CI: 0.93-2.79; P = 0.09; I² = 0%), suggesting that the larger effect in the primary analysis is driven mainly by a small number of moderate-to-serious risk studies enriched for warfarin-treated patients and more invasive, full-arch procedures. Individual study estimates demonstrated bleeding rates ranging from <1% to 27.5% depending on anticoagulant class and procedural complexity, with warfarin and highly invasive surgeries presenting the greatest risk. Importantly, all bleeding incidents were successfully managed with local hemostatic measures, and no life-threatening events were reported. While it is generally safe to continue antithrombotic agents when local protocols for dental implant placement are rigorously followed, individualized patient risk stratification is crucial. Future high-quality trials are needed to refine evidence-based guidelines and optimize perioperative management in this growing patient population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.