ArticleCureus2025
Fatal Spontaneous Rebleeding of Subdural Haematoma Following COVID-19 Infection: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
COVID-19 is associated with various neurological complications, including intracranial haemorrhage. However, spontaneous rebleeding of pre-existing subdural haematomas triggered by COVID-19 infection remains exceptionally rare. We report an 88-year-old woman with rheumatoid arthritis who presented with acute-on-chronic subdural haematoma following a fall. Conservative management was pursued, given her advanced age and comorbidities. After seven days of clinical stability, she contracted COVID-19 via PCR screening. Within 24 hours, she experienced catastrophic neurological deterioration (Glasgow Coma Scale declining from 15 to 3) without trauma or anticoagulation. Imaging confirmed worsening subdural haemorrhage with increased midline shift (12 mm) and acute rebleeding. Despite supportive care, she died 10 days later. This case demonstrates a temporal association between COVID-19 infection and fatal subdural haematoma rebleeding, possibly mediated through vascular injury, neuroinflammation, and coagulopathy. Patients with pre-existing intracranial haemorrhage who develop COVID-19 may require heightened neurological surveillance.
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