Evidence map›Paper›PMID 41503233›Full record

ArticlePhysics and imaging in radiation oncology2026

Feasibility of reusing online-generated treatment plans for adaptive radiotherapy in prostate cancer.

Sarah A Mason, Bethany Williams, Sophie Alexander, Alex Dunlop, Alison Tree, Emma J Harris, Helen McNair

Abstract read
In one paragraph

Article in Physics and imaging in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah A MasonDivision of Radiotherapy and Imaging, Institute of Cancer Research, London, UK.
Bethany WilliamsRadiotherapy Department, Royal Marsden NHS Foundation Trust, Sutton, UK.
Sophie AlexanderDivision of Radiotherapy and Imaging, Institute of Cancer Research, London, UK.
Alex DunlopDivision of Radiotherapy and Imaging, Institute of Cancer Research, London, UK.
Alison TreeDivision of Radiotherapy and Imaging, Institute of Cancer Research, London, UK.
Emma J HarrisDivision of Radiotherapy and Imaging, Institute of Cancer Research, London, UK.
Helen McNairDivision of Radiotherapy and Imaging, Institute of Cancer Research, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Purpose: : Online adaptive radiotherapy (oART) is underused as generating a treatment plan at every fraction is slow and resource intensive. One method to address this involves reusing plans generated online in previous fractions with similar anatomy. However, manually assessing the suitability of each pre-existing treatment plan is prohibitively time-consuming. To gauge potential impact and motivate the development of software to enable plan recycling, we assessed a strategy whereby Methods: The verification MR was used to estimate the delivered dose after adaptation to establish a Current Clinical Practice Benchmark. Each structure from the daily MR was propagated backwards onto the reference and daily MRs from previous fractions to calculate the dose to each structure that would have been received had the corresponding plan been delivered. The resulting dose statistics were assessed against: (A) standard target and organ-at-risk objectives, (B) the Current Clinical Practice Benchmark, and (C) circumstances where a pre-existing plan would have matched or outperformed the online plan. Results: The median [interquartile range] percentage of fractions with at least one acceptable pre-existing plan was 25% [20%], 40% [35%], and 60% [20%] for criteria A, B, and C respectively. Reusing the reference plan was only acceptable in 0%-20% of fractions. Conclusion: Reusing pre-existing plans is feasible and could accelerate oART and reduce hospital resources in approximately 40% of fractions whilst achieving the same dose-volume metrics as current oART workflows.

Indexed as

MR-linacOnline adaptive radiotherapyProstate cancer radiotherapyRadiotherapy workflow

Identifiers

PMID41503233
PMCPMC12771498

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.