Evidence map›Paper›PMID 41503214›Full record

ArticleiScience2026

Spatial single-cell profiling identifies protein kinase Cδ-expressing microglia with anti-tumor function in glioblastoma.

Reza Mirzaei, Reid McNeil, Charlotte D'Mello, Britney Wong, Susobhan Sarkar, Frank Visser, Candice Poon, Pinaki Bose, V Wee Yong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Reza MirzaeiDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.
Reid McNeilArnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada.
Charlotte D'MelloDepartment of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
Britney WongDepartment of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
Susobhan SarkarDepartment of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
Frank VisserHotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Candice PoonArnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada.
Pinaki BoseArnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada.
V Wee YongDepartment of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) contains diverse immune and tumor cell populations whose spatial organization influences disease progression. To better understand how immune cells interact with brain tumor-initiating cells (BTICs), we applied integrated single-cell and spatial transcriptomic approaches to map the immune landscape in a GBM mouse model. This analysis revealed a distinct subset of microglia expressing protein kinase Cδ (PKCδ) that localizes near BTIC-rich regions and displays features associated with anti-tumor activity. We validated the presence of PKCδ

Indexed as

CancerComponents of the immune systemModel organismTranscriptomics

Identifiers

PMID41503214
PMCPMC12768871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.