ArticleiScience2026
LAMP2A regulates endosomal protein composition and membrane identity in exosome biogenesis.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Annexin A6 controls multi-organelle contact site formation and endolysosomal positioning, and remodels the STARD3 interactome.iScience · 2026Article
- Protocol to isolate endosomal and small extracellular vesicles from cultured cells through ultracentrifugation.STAR protocols · 2026Article
- From pathogenic carriers to therapeutic hope: the dual role and translational prospects of exosomes in diabetic kidney disease.Frontiers in endocrinology · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endolysosomal system maintains cellular homeostasis through protein degradation and the release of exosomes that mediate intercellular communication. LAMP2A, a transmembrane protein, has been implicated in selective cargo loading into exosomes, or eLLoC. Here, we investigated how LAMP2A influences endosomal protein composition and function using mass spectrometry of endosomal and exosomal fractions from human retinal pigment epithelial cells. Loss of LAMP2A changed Rab GTPase distribution, reduced cortical actin association, and shifted phosphoinositide dynamics, leading to enhanced endosomal acidification and maturation. These changes extended beyond the loss of proteins containing ExoSignals, the canonical targeting motifs, suggesting that LAMP2A contributes broadly to endosomal identity. Experimental validation confirmed that LAMP2A deficiency reprograms endosomal fate toward degradation while influencing exosome composition. These findings highlight a role for LAMP2A in coordinating membrane identity, endosomal maturation, and intercellular communication through exosomes, providing insights into mechanisms that couple endosomal remodeling with cellular signaling and clearance pathways.
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Registered trials
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