ArticleKidney medicine2026
Time-Dependent Changes in Extracellular-to-Intracellular Water Ratios and Risk of All-Cause Mortality in Peritoneal Dialysis Patients: A Single-Center Retrospective Cohort Study.
Article in Kidney medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Rationale & Objective: Bioelectrical impedance spectroscopy (BIS) is a valuable tool for assessing body composition in patients on peritoneal dialysis (PD), as body composition can significantly change during long-term PD treatment. We aimed to clarify the relationship between time-dependent changes in the extracellular-to-intracellular water ratio (EIR) and all-cause mortality in patients undergoing long-term PD. Study Design: A single-center, retrospective cohort study. Setting & Participants: This study enrolled adult PD patients who underwent body composition measurements from our bioelectrical impedance spectroscopy-aided fluid management program from May 1, 2012, to April 30, 2023. Patients were followed up until death, withdrawal from PD, or the end of the study. Exposure: EIR and its covariates. Outcomes: All-cause mortality. Analytical Approach: Time-dependent Cox proportional hazards, restricted cubic splines, and propensity score matching analyzed risk factors and mortality. Results: Among the 468 PD patients, the median follow-up period was 2.0 (interquartile range [IQR] 0.6-4.3) years. Three distinct temporal EIR trajectories are found after grouping baseline EIR (bEIR) into quartiles ( Limitations: The study had a retrospective design. Conclusions: The EIR, regarded as either a time-independent or time-dependent variable, is a crucial predictor of mortality in PD patients under regular monitoring of fluid status. Our results also suggest that an EIR of ≥0.87 would be a useful target for predicting the long-term mortality of PD patients in clinical practice.
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