Evidence map›Paper›PMID 41503153›Full record

ArticleJBMR plus2026

Impact of clinical symptoms on quality of life in adult hypophosphatasia: a monocentric study in northern Germany.

Ron Niklas Krüger, Felix N von Brackel, Eik Vettorazzi, Laura Inhestern, Ralf Oheim, Michael Amling, Florian Barvencik

Abstract read
In one paragraph

Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ron Niklas KrügerDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 22529 Hamburg, Germany.ORCID https://orcid.org/0009-0006-8474-2475
Felix N von BrackelDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 22529 Hamburg, Germany.ORCID https://orcid.org/0000-0001-6586-6794
Eik VettorazziInstitute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID https://orcid.org/0000-0002-3737-6402
Laura InhesternDepartment of Medical Psychology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Ralf OheimDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 22529 Hamburg, Germany.ORCID https://orcid.org/0000-0001-9449-5013
Michael AmlingDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 22529 Hamburg, Germany.
Florian BarvencikDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 22529 Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult hypophosphatasia (HPP) is caused by genetic variations in the

Indexed as

alkaline phosphataseBPIhypophosphatasiapain localizationpatient reported outcomephysical status indicatorsquality of lifeSF-36

Identifiers

PMID41503153
PMCPMC12771374

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.