ArticleJBMR plus2026
Denosumab treatment of osteoporotic women arrests cortical bone remodeling events at the reversal-resorption phase but does not affect ongoing bone formation.
Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Denosumab is an anti-resorptive therapy that effectively reduces fracture risk and increases BMD in women with postmenopausal osteoporosis. In this study, we focused on the less well-investigated cortical remodeling process and its transition from erosion to formation after denosumab treatment, using a histomorphometric classification of intracortical pores. Cortical bone is more prominent in non-vertebral bones, where denosumab is less effective in fracture reduction. In iliac crest biopsies from the FREEDOM-study, where postmenopausal osteoporotic women were treated with placebo (
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