ArticleJournal of surgical case reports2026
Malignant adenomyoepithelioma of the breast: a rare case report and literature review.
Article in Journal of surgical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- A Rare Case of Adenomyoepithelioma of the Breast Complicated with Cyst Diagnosed by Preoperative Core Needle Biopsy: A Case Report.Surgical case reports · 2026Article
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7 authors.
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Abstract
Adenomyoepithelioma (AME) of the breast is a rare biphasic tumor composed of epithelial and myoepithelial elements, with malignant transformation being exceptionally uncommon. We report a case of pure malignant adenomyoepithelioma (M-AME) in a 51-year-old woman who presented with a gradually enlarging left breast mass. Imaging revealed a 3.6 cm lesion, and core biopsy showed biphasic proliferation with myoepithelial atypia and high mitotic activity. Wide local excision with oncoplastic reduction achieved negative margins, and histopathology confirmed pure M-AME (pT2 pN0), triple-negative for estrogen, progesterone, and Human Epidermal growth factor Receptor 2, with a Ki-67 index of 35%-40%. The patient received adjuvant radiotherapy and remains disease-free at 1 year. This case highlights the diagnostic challenges of M-AME, underscores the importance of immunohistochemistry and complete excision with negative margins, and adds to the limited literature on this exceptionally rare breast neoplasm.
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