ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Integrative Genetic Analysis of DPP4-Related Variants Reveals Risk Patterns for Type 2 Diabetes and Cardiometabolic Comorbidities.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hypertension (HTN) and dyslipidemia (DYS) frequently complicate type 2 diabetes mellitus (T2DM), increasing cardiovascular risk. Genetic variation within the Methods: A total of 444 T2DM patients were stratified into T2DM (n = 256), T2DM with HTN (T2MH, n = 134), and T2DM with HTN and DYS (T2MH-DYS, n = 54). Six single nucleotide polymorphisms (SNPs) were genotyped, and associations were assessed by logistic regression and haplotype analysis with Bonferroni correction. Results: Clinical profiling showed higher C-reactive protein (CRP) and adrenocorticotropic hormone (ACTH) in T2MH and more severe metabolic derangements in T2MH-DYS. DPP4 rs3788979 was strongly linked to hypertension: CT (adjusted OR = 0.370, Conclusion: Variants within the DPP4 axis influence susceptibility to HTN and DYS in T2DM, with GAATGT and GACCGT emerging as robust haplotype markers. Notably, the risk conferred by DPP4 rs3788979 genotypes was modulated by lipid status: CT/CC were protective against hypertension alone but became risk factors when dyslipidemia co-occurred.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.