Evidence map›Paper›PMID 41502980›Full record

ArticleBioactive materials2026

Bioinspired scaffold recapitulating chondrogenic ontogeny and microenvironment for functional cartilage regeneration.

Tianyu Yu, Xun Sun, Yang Liu, Yiming Dou, Ye Tian, Yiming Zhang, Genghao Wang, Lianyong Wang, Jianmin Han, Xiaohong Li and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tianyu YuDepartment of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, 300211, China.
Xun SunDepartment of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, 300211, China.
Yang LiuDepartment of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, 300211, China.
Yiming DouDepartment of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, 300211, China.
Ye TianDepartment of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, 300211, China.
Yiming ZhangDepartment of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, 300211, China.
Genghao WangDepartment of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, 300211, China.
Lianyong WangDepartment of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, 300211, China.
Jianmin HanDepartment of Orthodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China.
Xiaohong LiAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300071, China.
Xigao ChengDepartment of Orthopaedics, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Honglong LiShenzhen Healthemes Biotechnology Co. Ltd, Shenzhen, 518102, China.
Haobo PanShenzhen Healthemes Biotechnology Co. Ltd, Shenzhen, 518102, China.
Lei YangCenter for Health Sciences and Engineering (CHSE), Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, 300401, China.
Yanhong ZhaoDepartment of Orthodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China.
Qiang YangDepartment of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, 300211, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Focal articular cartilage defects often progress to osteoarthritis, imposing a substantial global health burden. Current neglect of cartilage developmental regulation and cartilage microenvironment compromises therapeutic efficacy. We developed an innovation CE-SKP/CPH/P2G3 scaffold which effectively repairs focal cartilage defects and emulates native cartilage ontogeny: the superficial CE-SKP hydrogel layer recruits SMSCs and promotes chondrogenesis; the middle CPH hydrogel layer induces chondrocyte hypertrophic calcification, forming cartilage calcified layer; and the basal P2G3 nanofiber membrane isolates subchondral cells, enforcing a top-down developmental sequence and preserving a localized hypoxic niche.

Indexed as

Calcified cartilageCartilageDecellularized extracellular matrix scaffoldSingle-cell RNA sequencingTissue engineering

Identifiers

PMID41502980
PMCPMC12771331

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.