Evidence map›Paper›PMID 41502951›Full record

ArticlebioRxiv : the preprint server for biology2025

Statistical design of a synthetic microbiome that suppresses diverse gut pathogens.

Rita A Oliveira, Emma McSpadden, Bipul Pandey, Kiseok Lee, Mahmoud Yousef, Robert Y Chen, Conrad Triebold, Fidel Haro, Valeryia Aksianiuk, Riya Patel and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rita A OliveiraDuchossois Family Institute, University of Chicago, Chicago, IL, 60637.
Emma McSpaddenDuchossois Family Institute, University of Chicago, Chicago, IL, 60637.
Bipul PandeyDuchossois Family Institute, University of Chicago, Chicago, IL, 60637.
Kiseok LeeDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, 60637.ORCID 0000-0002-3298-7116
Mahmoud YousefDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, 60637.
Robert Y ChenDepartment of Psychiatry, University of Washington, Seattle, WA, 98195.
Conrad TrieboldSection of Genetic Medicine, University of Chicago, Chicago, IL, 60637.
Fidel HaroPritzker School of Medicine, University of Chicago, Chicago, IL, 60637.
Valeryia AksianiukInstitute for Cell Biology, University of Bern, Bern, Switzerland.
Riya PatelUniversity of Illinois at Urbana Champagne, Urbana, IL, 61825.
Kaavya ShriramGrinnell College, Grinnell, IA, 50112.
Ramaswamy RamanujamDuchossois Family Institute, University of Chicago, Chicago, IL, 60637.
Seppe KuehnDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, 60637.
Arjun S RamanDuchossois Family Institute, University of Chicago, Chicago, IL, 60637.

Funding

Using co-evolution to understand the emergence of bacterial phenotype from proteome variationR35GM146702 · NIGMS · UNIVERSITY OF CHICAGO · PI Arjun Raman · 2022 to 2026
$2.0M
NIGMS NIH HHS R35 GM146702
6 · The paper itself

Abstract

Engineering functional microbiomes is challenging due to complex interactions between bacteria and their environments

Identifiers

PMID41502951
PMCPMC12773023

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.