Evidence map›Paper›PMID 41502927›Full record

ArticlebioRxiv : the preprint server for biology2026

A Cationic Amphiphilic Drug (CAD) Defense System in the Nematode

Levon Tokmakjian, Duhyun Han, Kateryna Sihuta, Aanchal Aggarwal, Somayeh Pirhadi, Yao Wang, Andrew R Burns, Brittany Cooke, Siyue Ren, Carolyn L Cummins and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Levon TokmakjianDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada.ORCID 0000-0003-1158-2731
Duhyun HanDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada.ORCID 0000-0002-0294-9020
Kateryna SihutaThe Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.ORCID 0009-0002-9150-6746
Aanchal AggarwalThe Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.ORCID 0000-0002-2072-9806
Somayeh PirhadiDepartment of Computational and Systems Biology, University of Pittsburgh, 4200 Fifth Ave, Pittsburgh, Pennsylvania 15260, United States.ORCID 0000-0002-7443-8078
Yao WangDepartment of Computational and Systems Biology, University of Pittsburgh, 4200 Fifth Ave, Pittsburgh, Pennsylvania 15260, United States.ORCID 0009-0006-3823-7160
Andrew R BurnsThe Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.ORCID 0000-0002-8966-1280
Brittany CookeThe Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.ORCID 0000-0002-6386-1655
Siyue RenDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Carolyn L CumminsDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-7603-6577
Justin NodwellDepartment of Biochemistry, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.ORCID 0000-0001-7909-1803
David R KoesDepartment of Computational and Systems Biology, University of Pittsburgh, 4200 Fifth Ave, Pittsburgh, Pennsylvania 15260, United States.ORCID 0000-0002-6892-6614
Peter J RoyDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada.ORCID 0000-0003-2959-2276

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
New Methods and Tools for Computational Drug Discovery: Diversity SupplementR35GM140753 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOES, DAVID RYAN · 2021 to 2025
$2.2M
NIGMS NIH HHS R35 GM140753NIH HHS P40 OD010440
6 · The paper itself

Abstract

Cationic Amphiphilic Drugs (CADs) severely disrupt lysosomal function, which leads to a cellular pathology characterized by excess phospholipids called phospholipidosis. Through a forward genetic screen and mining of published datasets, we discovered that CADs induce the expression of the CYP-35B family of cytochrome P450s and the PGP-13 p-glycoprotein pump via the nuclear receptors NHR-70 and NHR-107 in the nematode

Identifiers

PMID41502927
PMCPMC12773005

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.