Evidence map›Paper›PMID 41502908›Full record

ArticleOpen forum infectious diseases2026

Characteristics and Outcomes of Patients With Hematologic Malignancies Hospitalized With Respiratory Viral Infections.

Zulfiqar A Lokhandwala, Brenna Park-Egan, Ravneet Waraich, Colleen A McEvoy, Andrew P Michelson, Alice F Bewley, Lynne Strasfeld, Rachel Cook, Brandon Hayes-Lattin, Catherine L Hough and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zulfiqar A LokhandwalaSchool of Medicine, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-5000-4611
Brenna Park-EganDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Ravneet WaraichDepartment of Medicine, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0001-7735-5174
Colleen A McEvoyDivision of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.
Andrew P MichelsonDivision of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.
Alice F BewleyDivision of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.ORCID https://orcid.org/0000-0001-5392-4010
Lynne StrasfeldDivision of Infectious Diseases, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Rachel CookDivision of Hematology and Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Brandon Hayes-LattinDivision of Hematology and Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Catherine L HoughDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Patrick G LyonsDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-1557-2787

Funding

High Performance Computing and Machine Learning Infrastructure for Oregon Life SciencesS10OD034224 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLROTT, KYLE · 2023 to 2023
$2.0M
SPOT-IT: Sepsis Prediction in Oncology Through Implementation Science and TechnologyK08CA270383 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Patrick G Lyons · 2024 to 2026
$851k
NCI NIH HHS K08 CA270383NIH HHS S10 OD034224
6 · The paper itself

Abstract

Background: Respiratory viral infections in patients with hematologic malignancies or hematopoietic stem cell transplants (HCTs) are associated with increased morbidity and mortality. However, the hospital presentations and courses of these infections remain under-described. Methods: We performed a multicenter retrospective cohort study of hospitalized patients with hematologic malignancy or HCT at 2 comprehensive cancer centers between January 2019 and June 2023. We included all patients with acute viral respiratory infection (identified based on a constellation of test results and objective physiology), comparing clinical presentations, care processes, and patient outcomes across pathogens; the primary outcome was the composite of hospital death or discharge to hospice. Results: We evaluated 385 hospitalizations from 346 unique patients, 162 (42%) of which were for SARS-CoV-2 infection. The primary outcome of death or discharge to hospice occurred in 54 (14%) encounters and did not significantly differ across pathogens ( Interpretation: Among hospitalized patients with hematologic malignancies or HCTs, acute viral respiratory infections display similar initial physiology and outcomes regardless of pathogen. These findings may have implications for clinical practice.

Indexed as

hematologic malignanciespneumoniarespiratory infectionsviral infection

Identifiers

PMID41502908
PMCPMC12771646

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.