ArticleTranslational pediatrics2025
Transcription factor activity-based stratification reveals prognostic subtypes and immune landscape in neuroblastoma.
Article in Translational pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: High-risk neuroblastoma (NB) still carries a <50% long-term survival despite risk-adapted therapy. Conventional risk metrics (age, stage, Methods: TF activities for 498 primary NB tumors (GSE49710) were inferred with decoupleR-univariate linear model (ULM) using the OmniPath regulon. TFs that were significantly associated with overall survival (OS; Cox; P<1×10-4; n=146) were subjected to consensus clustering and Boruta-guided principal component analysis (PCA) to create a continuous TF_score. Immune infiltration and immunotherapy surrogates, Immunophenoscore (IPS) and the Tumor Immune Dysfunction and Exclusion (TIDE) framework, were compared across TF_score strata. A nomogram integrating TF_score, stage, and Results: Two robust NB subtypes were identified, with cluster 2 associated with worse prognosis, Conclusions: TF activity profiling provides robust stratification for NB, integrating clinical prognostication and immune characterization. This study offers novel insights into TF-driven NB biology, with implications for targeted therapy and immunotherapeutic strategies.
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