ArticleTranslational pediatrics2025
Constructing a precise prediction model for screening growth hormone deficiency in children in a single laboratory setting: using the serum IGF-1-to-age ratio as a promising predictive marker.
Article in Translational pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Growth hormone deficiency (GHD) requires accurate diagnosis, but the current gold standard, the growth hormone (GH) stimulation test, is highly invasive and resource-intensive, thus necessitating effective screening methods. Insulin-like growth factor 1 (IGF-1) is the most commonly utilized predictive marker for GHD. However, the consistency and accuracy of serum IGF-1 tests can be affected by patient characteristics and technical issues in blood analysis, which complicates its use as a reliable standalone marker. This study investigated the performance of the IGF-1/age ratio as a predictive marker for GHD and constructed a precise prediction model to mitigate these sources of variability in a single laboratory setting. Methods: This cross-sectional study included 352 children aged 3 to 9 years who presented to Xi'an Children's Hospital for short stature and underwent the GH stimulation testing, which served as the gold standard for GHD diagnosis (peak GH cutoff of 10 µg/L). Key exclusion criteria were body mass index (BMI) ≥25 kg/m Results: A total of 117 participants (33.2%) exhibited GHD based on the GH stimulation test. The GHD group exhibited significantly lower levels of IGF-1 (82.19 Conclusions: Based on data from this single-center study, our results suggest that the IGF-1/age ratio is a promising predictive marker that may be used to effectively stratify GHD risk and facilitate fast screening prior to definitive GH stimulation testing.
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