ArticleACS omega2025
Magnetic Fluid Hyperthermia-Induced Apoptosis: Evaluating the Effect of Ho-Doped Mn-Zn Magnetic Nanoparticles on Cervical, Breast, and Bone Cancer Cells in Vitro.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Doping rare-earth metals is known to enhance the efficiency of magnetic nanoparticles and, consequently, improve magnetic fluid hyperthermia (MFH), which is emerging as a promising anticancer therapeutic strategy with expected minimal side effects. In this study, the synthesis of holmium (Ho)-doped temperature-sensitive Mn-Zn ferrite nanoparticles using the chemical coprecipitation method is reported. The biocompatibility and intracellular uptake of the synthesized fluid were investigated by using MTT assay- and Prussian blue staining across a variety of cancer cell lines, including cervical (HeLa), breast (MCF-7), and bone (MG-63). Moreover, following MFH, apoptotic cell death was confirmed using Hoechst/PI staining and quantified through flow cytometry after Annexin-V labeling. The expression of selected apoptotic proteins was demonstrated by western blotting. The cells demonstrated the biocompatibility and fair internalization of the magnetic fluid at concentrations sufficient for MFH. Combined intra- and extracellular MFH studies revealed the effective induction of apoptosis in these cells. The findings highlight the potential of Ho-doped Mn-Zn magnetic fluid for cancer therapeutics through MFH.
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