Evidence map›Paper›PMID 41502755›Full record

ArticleACS omega2025

Repurposed Arylidene-hydrazinyl-1,3-thiazoles as Multitarget Anti-Alzheimer's Agents via Combined Computational and Experimental Studies.

Danuta Drozdowska, Artur Ratkiewicz, Agnieszka Wróbel-Tałałaj, Cezary Parzych, Hadeel A El-Dershaby, Heba A Abd El-Razik, Farid S G Soliman, Marwa H El-Wakil

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Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Danuta DrozdowskaDepartment of Organic Chemistry, Medical University of Bialystok, Mickiewicza Street 2A, 15-222 Bialystok, Poland.ORCID https://orcid.org/0000-0002-3479-0480
Artur RatkiewiczDepartment of Physical Chemistry, Institute of Chemistry, University of Bialystok, Ciołkowskiego 1K Street, 15-245 Bialystok, Poland.ORCID https://orcid.org/0000-0003-1657-1871
Agnieszka Wróbel-TałałajDepartment of Organic Chemistry, Medical University of Bialystok, Mickiewicza Street 2A, 15-222 Bialystok, Poland.
Cezary ParzychDepartment of Physical Chemistry, Institute of Chemistry, University of Bialystok, Ciołkowskiego 1K Street, 15-245 Bialystok, Poland.
Hadeel A El-DershabyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
Heba A Abd El-RazikDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
Farid S G SolimanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
Marwa H El-WakilDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In quest of new and potent multitarget therapeutics for Alzheimer's disease (AD), a series of recently synthesized arylidene-hydrazinyl-thiazoles were repurposed as multitarget directed anti-AD agents. In total, 14 compounds were tested for their inhibitory activities against the key enzymes acetylcholinesterase (AChE), β-secretase 1 (BACE1), and butyrylcholinesterase (BChE). Derivatives

Identifiers

PMID41502755
PMCPMC12771191

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.