ArticleACS omega2025
Impedimetric Graphene-Based Gold Immunosensor for Colorectal Cancer Biomarker CCSP‑2 Detection.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Electrochemical immunosensors are emerging as promising tools for cancer detection due to their simplicity, portability, and high sensitivity. Colorectal cancer (CRC), the third most common cancer in the United States, remains challenging to diagnose early, as the standard method, colonoscopy, is invasive and often avoided. To address this gap, a graphene-gold-based immunosensor was developed for the early detection of CRC by targeting colon cancer-secreted protein-2 (CCSP-2), a biomarker overexpressed in CRC patients. The sensor was fabricated by attaching graphene oxide (GO) to a gold (Au) electrode using 4-aminothiophenol (4-ATP) as a linker, followed by immobilization of CCSP-2 antibodies (Anti-CCSP-2) and blocking with bovine serum albumin (BSA). Characterization of the immunosensor using linear sweep voltammetry (LSV), Raman spectroscopy, cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS) confirmed successful modifications. The attachment of graphene oxide contributed to an enhancement in current response, likely due to partial reduction and improved electron transfer at the modified surface. The sensor demonstrated a good linear response (
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