Evidence map›Paper›PMID 41502567›Full record

ArticleResearch square2025

Jk Dna Gaga Motifs Are Required for Local Nucleosome Remodeling and Vk-jk Recombination.

Marcus Clark, Margaret Veselits, Kaitlin McLean, Nathaniel Wright, Michael Okoreeh, Jacob Veselits, Mark Maienschein-Cline, Malay Mandal

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marcus ClarkUniversity of Chicago.ORCID https://orcid.org/0000-0003-4747-0387
Margaret VeselitsUniversity of Chicago.ORCID https://orcid.org/0000-0001-8755-6260
Kaitlin McLeanDepartment of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago.
Nathaniel WrightUniversity of Chicago.ORCID https://orcid.org/0000-0001-7006-4040
Michael OkoreehUniversity of Chicago.
Jacob VeselitsUniversity of Chicago.
Mark Maienschein-ClineUniversity of Illinois at Chicago.
Malay MandalUniversity of Chicago.ORCID https://orcid.org/0000-0002-0451-3896

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1M
Role of CXCR4 in immunoglobulin light chain recombinationR01AI150860 · NIAID · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY, MANDAL, MALAY · 2021 to 2025
$2.9M
The epigenetic reader BRWD1 in peripheral adaptive immunityR01AI143778 · NIAID · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 2019 to 2023
$2.4M
NCI NIH HHS P30 CA014599NIAID NIH HHS R01 AI143778NIAID NIH HHS R01 AI150860
6 · The paper itself

Abstract

Immunoreceptor gene recombination requires complementary 12 bp and 23 bp recombination signal sequences (RSSs). In addition, at RSSs where RAG proteins assemble, recombination centers must be accessible yet have a proximate nucleosome decorated with H3K4me3 for RAG2 recruitment. In

Identifiers

PMID41502567
PMCPMC12772690

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.