Evidence map›Paper›PMID 41502557›Full record

ArticleClinical and translational radiation oncology2026

Clinical practice, barriers to implementation, and priorities for equitable access of Stereotactic Body Radiation Therapy: An analysis of the global status by the ESTRO SBRT Focus Group.

Ciro Franzese, Stephanie Tanadini-Lang, Dirk Verellen, Lisa Wiersema, Juliane Hörner-Rieber, Alejandra Méndez Romero, David Pasquier, Anna Bruynzeel, Judit Boda-Heggemann, Tom Depuydt and 16 more

Abstract read
In one paragraph

Article in Clinical and translational radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Ciro FranzeseDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Stephanie Tanadini-LangDepartment of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Dirk VerellenDepartment of Radiation Oncology, Iridium Network, Wilrijk (Antwerp), Belgium, Integrated Personalised and Precision Oncology Network, University Antwerp, Antwerp, Belgium.
Lisa WiersemaDepartment of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Juliane Hörner-RieberDepartment of Radiation Oncology, Duesseldorf University Hospital, Duesseldorf, Germany.
Alejandra Méndez RomeroDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands.
David PasquierAcademic Department of Radiation Oncology, Centre Oscar-Lambret, Lille, France.
Anna BruynzeelDepartment of Radiation Oncology, Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands, Cancer Center Amsterdam, Amsterdam, Netherlands.
Judit Boda-HeggemannDepartment of Radiation Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Tom DepuydtUniversity Hospitals Leuven, Radiation Oncology, Belgium.
Patrik SiboltDepartment of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
Najma DouirDepartment of Radiation Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Łukasz KuncmanDepartment of Radiotherapy, Medical University of Lodz, Łódź, Poland.
Casper BeijstDepartment of Radiotherapy, Utrecht University and University Medical Center Utrecht, Utrecht, the Netherlands.
Harley StephensUniversity Hospitals Bristol and Weston, United Kingdom.
Carolina de la PintaRadiation Oncology, Ramón y Cajal University Hospital, Madrid. Biomarkers and Therapeutic Targets Group, IRYCIS, Madrid, Spain.
Francesco CucciaRadiation Oncology, ARNAS Civico Hospital, Palermo, Italy.
Maaike MilderDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands.
Luca NicosiaAdvanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, Cancer Care Center, Verona, Italy.
Hiroshi OnishiDepartment of Radiology, University of Yamanashi, Yamanashi, Japan.
Alexander V LouieDepartment of Radiation Oncology, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.
Arjun SahgalDepartment of Radiation Oncology, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.
Simon S LoDepartment of Radiation Oncology and Department of Neurological Surgery, University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Ben J SlotmanDepartment of Radiation Oncology, Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands, Cancer Center Amsterdam, Amsterdam, Netherlands.
Matthias GuckenbergerDepartment of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Marta ScorsettiDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Stereotactic Body Radiation Therapy (SBRT) has become an established treatment for several primary and metastatic malignancies; however, considerable heterogeneity remains in its definition, clinical indications, and technical delivery. Methods: In May 2025, the SBRT Focus Group of the European Society for Radiotherapy and Oncology (ESTRO), in collaboration with International Stereotactic Radiosurgery Society (ISRS), the Radiosurgery Society (RSS), and the Japanese Society for Radiation Oncology (JASTRO), conducted a global survey. A 44-item questionnaire explored SBRT indications, technical aspects, dose/fractionation, and barriers to implementation. Descriptive statistics summarized the responses. Results: Overall, 289 professionals from 59 countries participated. Routine use of SBRT was reported by 96.6 % of respondents, with lung, bone, liver and prostate as the most frequent indications. Pancreatic tumor (48.4 %), renal cell carcinoma (46.4 %), and ventricular tachycardia (12.4 %) represented emerging indications. C-arm linacs (89.2 %) and in-room Cone beam CT (CBCT) (92.0 %) were the dominant technologies. Motion management relied mainly on 4D-CT internal target volume (ITV) (88.9 %) and deep inspiration breath-hold (DIBH) (57.8 %). Fractionation was consistent for lung and prostate but heterogeneous for liver, and pancreas. Only 3.5 % reported routine use of online adaptive SBRT, while 61.5 % reported artificial intelligence (AI) use, mainly for organs-at-risk delineation. Key barriers included limited clinical trial funding (35.2 %), high equipment costs (34.2 %), insufficient reimbursement (27.7 %), and workforce shortages (33.9 %). Conclusions: This ESTRO international survey provides the first global overview of SBRT practices. It demonstrates broad adoption but also substantial variability, highlighting the need for consensus guidelines, greater trial access, and expanded education to harmonize SBRT delivery and ensure equitable care worldwide.

Indexed as

Ablative radiotherapyAdvanced radiotherapyRadiation oncologySABRSBRTStereotactic body radiation therapyStereotactic radiotherapy

Identifiers

PMID41502557
PMCPMC12771324

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.